-
1.发明授权2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权2-氨基噻唑衍生物，其制备方法及其作为抗癌剂的用途
公开(公告)号：EP1124810B1
公开(公告)日：2005-05-04
申请号：EP99955931.3
申请日：1999-10-27
发明人： PEVARELLO, Paolo , AMICI, Raffaella , TRAQUANDI, Gabriella , VILLA, Manuela , VULPETTI, Anna , ISACCHI, Antonella
IPC分类号： C07D277/46 , C07D417/12 , A61K31/426 , A61K31/427 , A61P35/00
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/46
-
2.发明公开BICYCLO-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开双环吡唑衍生物激酶抑制剂，PROCESS FOR THEIR和药物成分，以便
公开(公告)号：EP1608364A1
公开(公告)日：2005-12-28
申请号：EP04716253.2
申请日：2004-03-02
IPC分类号： A61K31/4162 , C07D487/04
CPC分类号： C07D487/04 , A61K31/4162 , A61K31/4745 , A61K31/55
摘要： Compounds which are pyrrolo-pyrazole derivatives and pharmaceutically acceptable salts thereof, together with the process for their preparation and pharmaceutical compositions thereof are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
-
公开(公告)号：EP1177185B1
公开(公告)日：2005-04-20
申请号：EP00927184.2
申请日：2000-05-04
IPC分类号： C07D401/04 , C07D231/56 , A61K31/416 , A61P35/00
CPC分类号： C07D401/04 , C07D231/56
-
4.发明公开BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开作为激酶抑制剂的ACTIVE BICYCLOPYRAZOLE，METHOD用于生产和含有YOU的药物组合物
公开(公告)号：EP1527074A1
公开(公告)日：2005-05-04
申请号：EP03738125.8
申请日：2003-07-16
IPC分类号： C07D487/04 , A61K31/415 , A61P35/00
CPC分类号： C07D487/04 , A61K31/415 , A61K45/06 , C07D471/04 , A61K2300/00
摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrrolo-pyrazole or pyrazolo-azepine. The invention also provides specific pyrrolo-pyrazoles and pyrazolo-azepines, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
-
5.发明公开PHENYLACETAMIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权苯乙酰胺基噻唑化合物，工艺作为生产，它们作为抗肿瘤药
公开(公告)号：EP1406899A2
公开(公告)日：2004-04-14
申请号：EP02760213.5
申请日：2002-07-02
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario , BRASCA, Maria, Gabriella , TRAQUANDI, Gabriella , NESI, Marcella
IPC分类号： C07D417/12 , C07D277/46 , A61K31/425 , A61P35/00
CPC分类号： C07D417/12 , C07D277/46
摘要： Compounds represented by formula (I), as defined in the description, wherein R is a hydrogen atom or a methyl group and R1 is a group as defined in the specification, or a pharmaceutically acceptable salt thereof, are disclosed; the said compounds are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
-
6.发明授权2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权2 AMINOTHIAZOLEDERIVATE，生产方式及其作为抗肿瘤药
公开(公告)号：EP1124810B9
公开(公告)日：2005-12-28
申请号：EP99955931.3
申请日：1999-10-27
发明人： PEVARELLO, Paolo , AMICI, Raffaella , TRAQUANDI, Gabriella , VILLA, Manuela , VULPETTI, Anna , ISACCHI, Antonella
IPC分类号： C07D277/46 , C07D417/12 , A61K31/426 , A61K31/427 , A61P35/00
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , C07D277/46
-
7.发明公开BICYCLO-PYRAZOLES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 审中-公开双环吡唑有效的激酶抑制剂，用于生产和含有药物组合物
公开(公告)号：EP1526852A1
公开(公告)日：2005-05-04
申请号：EP03738106.8
申请日：2003-07-01
IPC分类号： A61K31/437 , A61P25/28 , A61P35/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a pyrazole-tetrahydro pyridine derivative. The invention also provides specific pyrazole-tetrahydro pyridines, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
-
8.发明公开
公开(公告)号：EP1345909A1
公开(公告)日：2003-09-24
申请号：EP01983600.6
申请日：2001-11-22
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , BRASCA, Maria, Gabriella , AMICI, Raffaella , VILLA, Manuela , PIUTTI, Claudia , VARASI, Mario , LONGO, Antonio
IPC分类号： C07D231/40 , C07D413/12 , C07D403/12 , C07D401/12 , A61K31/415 , A61P35/00
CPC分类号： C07D401/12 , C07D231/40 , C07D403/12 , C07D413/12
摘要： Phenylacetamido-pyrazoles of Formula (I) and, more particularly, N-(5-cycloalkyl-1H-pyrazol-3-yl) phenylacetamido derivatives, optionally further substituted as reported in the description; or pharmaceutically acceptable salts thereof; are useful in the treatment of cell proliferative disorders, e.g.cancer, associated with an altered cell cycle dependent kinase activity. Formula (I).
-
9.发明公开ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS 有权芳羰噻唑衍生物及其作为抗肿瘤药物使用
公开(公告)号：EP1204649A1
公开(公告)日：2002-05-15
申请号：EP00962760.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario
IPC分类号： C07D277/46 , C07D417/12 , C07D417/14 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/497 , A61P35/00
CPC分类号： A61K31/426 , C07D277/46
摘要： 2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts thereof, are useful in, for example, the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenertive diseases.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.016 秒)
