发明公开
EP1554576A2 IDENTIFICATION OF HIGH AFFINITY MOLECULES BY LIMITED DILUTION SCREENING
有权
鉴定高亲和力的分子通过有限稀释筛选
- 专利标题： IDENTIFICATION OF HIGH AFFINITY MOLECULES BY LIMITED DILUTION SCREENING
- 专利标题（中）： 鉴定高亲和力的分子通过有限稀释筛选
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申请号： EP02792319.2申请日： 2002-12-02
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公开(公告)号： EP1554576A2公开(公告)日： 2005-07-20
- 发明人: BABCOOK, John , KANG, Jaspal, Singh , JIA, Xiao-Chi , ZHANG, Li
- 申请人： Abgenix, Inc.
- 申请人地址： 7601 Kaiser Drive Fremont, CA 94555 US
- 专利权人： Abgenix, Inc.
- 当前专利权人： Abgenix, Inc.
- 当前专利权人地址： 7601 Kaiser Drive Fremont, CA 94555 US
- 代理机构： Brants, Johan Philippe Emile
- 优先权： US337250P 20011203
- 国际公布： WO2003048730 20030612
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; G01N33/537 ; G01N33/566 ; G01N33/557
摘要：
Methods are disclosed for determining the relative binding affinities of molecules for their binding partner. One type of molecule is an antibody, which has an antigen binding partner. Antibodies are tested for binding against limited dilutions of antigen. Antibodies that bind to the most dilute antigen concentrations are determined to have a higher relative binding affinity for the antigen than antibodies that only bind to more concentrated antigen preparations.
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