公开(公告)号：EP1461081A2

公开(公告)日：2004-09-29

申请号：EP02786850.4

申请日：2002-12-02

申请人： Abgenix, Inc.

发明人： FOLTZ, Ian ,  BABCOOK, John ,  PALATHUMPAT, Varghese ,  YANG, Xiao-dong ,  KING, Chadwick, T.

IPC分类号： A61K39/395 ,  C07K16/28 ,  C12N15/13

CPC分类号： C07K16/289 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/56

摘要： Antibodies which specifically recognize the human CD45 isoform RB are presented. These antibodies may be used to block undesirable immune reactions in patients with transplant rejection and autoimmune diseases such as rheumatoid arthritis, multiple sclerosis and autoimmune diabetes. Preferred antibodies are fully human, monoclonal antibodies.

公开(公告)号：EP1466177A2

公开(公告)日：2004-10-13

申请号：EP02789983.0

申请日：2002-12-02

申请人： Abgenix, Inc.

发明人： WALKER, Wynn, L. ,  JIA, Xiao-Chi ,  GALLO, Michael ,  KANG, Jaspal, Singh ,  BABCOOK, John ,  DAVIS, Geoff ,  GREEN, Larry ,  JOHO, Keith

IPC分类号： G01N33/53

CPC分类号： C40B30/04 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/68 ,  G01N33/6845 ,  G01N2500/04

摘要： Methods to screen antibodies against an antigen, categorize them according to the epitope they recognize, and rank them according to their binding affinities, thereby providing a method to rapidly and efficiently identify antibodies having potential usefulness in therapeutic products are described. Also described are methods of evaluating antibodies to determine their potential usefulness in therapeutic products.

公开(公告)号：EP1554576B1

公开(公告)日：2007-10-03

申请号：EP02792319.2

申请日：2002-12-02

申请人： Abgenix, Inc.

发明人： BABCOOK, John ,  KANG, Jaspal, Singh ,  JIA, Xiao-Chi ,  ZHANG, Li

IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/566 ,  G01N33/557

CPC分类号： G01N33/6854 ,  G01N33/6857

摘要： Methods are disclosed for determining the relative binding affinities of molecules for their binding partner. One type of molecule is an antibody, which has an antigen binding partner. Antibodies are tested for binding against limited dilutions of antigen. Antibodies that bind to the most dilute antigen concentrations are determined to have a higher relative binding affinity for the antigen than antibodies that only bind to more concentrated antigen preparations.

公开(公告)号：EP1554576A2

公开(公告)日：2005-07-20

申请号：EP02792319.2

申请日：2002-12-02

申请人： Abgenix, Inc.

发明人： BABCOOK, John ,  KANG, Jaspal, Singh ,  JIA, Xiao-Chi ,  ZHANG, Li

IPC分类号： G01N33/53 ,  G01N33/537 ,  G01N33/566 ,  G01N33/557

CPC分类号： G01N33/6854 ,  G01N33/6857

摘要： Methods are disclosed for determining the relative binding affinities of molecules for their binding partner. One type of molecule is an antibody, which has an antigen binding partner. Antibodies are tested for binding against limited dilutions of antigen. Antibodies that bind to the most dilute antigen concentrations are determined to have a higher relative binding affinity for the antigen than antibodies that only bind to more concentrated antigen preparations.