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232 条记录 (耗时 0.021 秒)

    METHODS, KITS AND APPARATUS FOR EXPANDING A POPULATION OF CELLS
    5.
    发明公开
    METHODS, KITS AND APPARATUS FOR EXPANDING A POPULATION OF CELLS 审中-公开

    公开(公告)号：EP3988920A1

    公开(公告)日：2022-04-27

    申请号：EP21191440.3

    申请日：2015-04-16

    申请人： Juno Therapeutics GmbH

    发明人： GERMEROTH, Lothar ,  STEMBERGER, Christian

    IPC分类号： G01N1/30 ,  G01N33/557 ,  C12N5/0783

    摘要： The present invention relates to in vitro -methods of expanding a population of cells such as lymphocytes, comprising contacting a sample comprising a population of cells with a multimerization reagent. The multimerization reagent has reversibly immobilized thereon (bound thereto) a first agent that provides a primary activation signal to the cells and optionally, a second agent that provides a co-stimulatory signal. The invention also provides multimerization reagents, kits, arrangements and an apparatus for expanding cells.

    SCREENING OF PROTEIN CANDIDATES
    7.
    发明授权
    SCREENING OF PROTEIN CANDIDATES 有权
    筛选VON PROTEINKANDIDATEN

    公开(公告)号：EP2467485B1

    公开(公告)日：2017-04-12

    申请号：EP10809397.2

    申请日：2010-08-18

    申请人： National Research Council of Canada

    发明人： ZHANG, Jianbing ,  HIRAMA, Tomoko

    IPC分类号： C12N15/62 ,  C07K19/00 ,  G01N33/68 ,  G01N33/557

    CPC分类号： G01N33/557 ,  C07K14/765 ,  C07K16/283 ,  C07K2317/21 ,  C07K2317/22 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/74 ,  C12N15/62 ,  G01N33/6803

    摘要： Successful application of an engineered protein as therapeutics or in other industries would require the protein to have good expression level, good biophysical properties and often desired affinity to its target. The present invention provides a method of screening large numbers of protein candidates (PCs) in all three aspects simultaneously. PCs are fused to a protein anchor, which is captured by the target/antigen. The captured PCs are evaluated for their expression levels, biophysical properties and affinities using conventional methods.

    摘要翻译： 成功应用工程蛋白作为治疗剂或其他行业将需要蛋白质具有良好的表达水平，良好的生物物理性质，并且通常对其靶标具有期望的亲合力。 本发明提供了在所有三个方面同时筛选大量蛋白质候选物（PC）的方法。 PC融合到被靶/抗原捕获的蛋白质锚。 使用常规方法评估所捕获的PC的表达水平，生物物理性质和亲和力。

    METHODS, KITS AND APPARATUS FOR EXPANDING A POPULATION OF CELLS
    8.
    发明公开
    METHODS, KITS AND APPARATUS FOR EXPANDING A POPULATION OF CELLS 审中-公开
    VERFAHREN，KITS UND VORRICHTUNG ZUR ERWEITERUNG EINER ZELLPOPULATION

    公开(公告)号：EP3132247A2

    公开(公告)日：2017-02-22

    申请号：EP15720620.2

    申请日：2015-04-16

    申请人： Juno Therapeutics GmbH

    发明人： GERMEROTH, Lothar ,  STEMBERGER, Christian

    IPC分类号： G01N1/30 ,  G01N33/557 ,  C12N5/0783

    CPC分类号： C12N5/0636 ,  C12M47/02 ,  C12M47/12

    摘要： The present invention relates to in vitro-methods of expanding a population of cells such as lymphocytes, comprising contacting a sample comprising a population of cells with a multimerization reagent. The multimerization reagent has reversibly immobilized thereon (bound thereto) a first agent that provides a primary activation signal to the cells and optionally, a second agent that provides a co-stimulatory signal. The invention also provides multimerization reagents, kits, arrangements and an apparatus for expanding cells.

    摘要翻译： 本发明涉及扩大淋巴细胞群体的体外方法，包括将包含细胞群的样品与多聚化试剂接触。 多聚化试剂在其上可逆地固定在其上（与之结合）第一试剂，其向细胞提供主要激活信号，以及任选地，提供共刺激信号的第二试剂。 本发明还提供多聚化试剂，试剂盒，布置和用于扩增细胞的装置。