发明公开
- 专利标题： T CELL RECEPTOR DISPLAY
- 专利标题（中）： T细胞受体“DISPLAY”
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申请号： EP03811009.4申请日： 2003-10-30
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公开(公告)号： EP1558643A2公开(公告)日： 2005-08-03
- 发明人: JAKOBSEN, Bent, Karsten,Avidex Limited , ANDERSEN, Torben, Bent,Avidex Limited , MOLLOY, Peter, Eamon,Avidex Limited , LI, Yi,Avidex Limited , BOULTER, Jonathan, Michael,Avidex Limited
- 申请人： Avidex Limited
- 申请人地址： 57C Milton Park Abingdon,Oxfordshire OX14 4RX GB
- 专利权人： Avidex Limited
- 当前专利权人： Avidex Limited
- 当前专利权人地址： 57C Milton Park Abingdon,Oxfordshire OX14 4RX GB
- 代理机构： Walls, Alan James
- 优先权： GB0226227 20021109; GB0301814 20030125; GB0304067 20030222; US463046P 20030416; GB0311397 20030516; GB0316356 20030711
- 国际公布： WO2004044004 20040527
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C12N15/10
摘要：
A proteinaceous particle, for example a bacteriophage, ribosome or cell, displaying on its surface a T-cell receptor (TCR). The displayed TCR is preferably a heterodimer having a non-native disulfide bond between constant domain residues. Such display particles may be used for the creation of diverse TCR libraries for the identificaton of high affinity TCRs. Several high affinities are disclosed.
公开/授权文献
- EP1558643B1 T CELL RECEPTOR DISPLAY 公开/授权日：2009-05-27
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