利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

14 条记录 (耗时 0.014 秒)

    SOLUBLE T CELL RECEPTOR
    3.
    发明授权
    SOLUBLE T CELL RECEPTOR 有权
    INSTANT T细胞受体

    公开(公告)号：EP1421115B1

    公开(公告)日：2005-03-02

    申请号：EP02755287.6

    申请日：2002-08-30

    申请人： Avidex Limited

    发明人： JAKOBSEN, Bent Karsten, Avidex Limited ,  GLICK, Meir

    IPC分类号： C07K14/725

    CPC分类号： C07K14/7051 ,  A61K38/00

    摘要： The present invention provides a soluble T cell receptor (sTCR), which comprises (i) all for part of a TCR α chain, except the transmembrane domain thereof, and (ii) all or part of a TCR β chain, except the transmembrane domain thereof. (i) and (ii) each comprise a functional variable domain and at least a part of the constant domain of the TCR chain, and are linked by a disulphide bond between constant domain residues which is not present in native TCR.

    IMMUNO INHIBITORY PYRAZOLONE COMPOUNDS
    4.
    发明公开
    IMMUNO INHIBITORY PYRAZOLONE COMPOUNDS 有权
    免疫阻燃吡唑啉酮CONNECTIONS

    公开(公告)号：EP1703906A1

    公开(公告)日：2006-09-27

    申请号：EP04798360.6

    申请日：2004-11-02

    申请人： Avidex Limited

    发明人： MATTHEWS, Ian, Richard

    IPC分类号： A61K31/4152 ,  C07D231/22 ,  A61P37/00 ,  A61P19/02 ,  C07D401/14 ,  C07D413/14 ,  C07D405/14 ,  C07D401/12 ,  C07D401/04 ,  C07D405/04

    CPC分类号： C04B35/632 ,  C07D231/22 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14

    摘要： Compounds of formula (IA) or (IB) are inhibitors of CD80 and useful in immunomodulation therapy: wherein Ar represents an optionally substituted monocyclic or bicyclic aromatic or heteroaromatic group having from 5 to 10 ring atoms; R1 and R2 independently represent H, or Cl-C6 alkyl; R3 represents H; F; CI; Br; -NO2; - CN; C1-C6 alkyl optionally substituted by F or CI; or C1-C6 alkoxy optionally substituted by F; R4 represents a carboxylic acid group (-COOH) or an ester thereof, or -C(=O)NR6R7, -NR7C(=O)R6, -NR7C(=O)OR6, -NHC(=O)NR7R6 or -NHC(=S)NR7R6 wherein R6 represents H, or a radical of formula -(Alk)m-Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C1-C12 alkylene, or C2-C12 alkenylene, or C2-C12 alkynylene radical or a divalent C3-C12 carbocyclic radical, any of which radicals may be interrupted by one or more -0-, -S- or -N(R8)- radicals wherein R8 represents H or C1-C4 alkyl, C3-C4 alkenyl, C3-C4 alkynyl, or C3-C6 cycloalkyl, and Q represents H; -CF3;-OH; -SH; -NR8R8wherein each R8 may be the same or different, or form a ring when taken together with the nitrogen to which they are attached; an ester group; or an optionally substituted aryl, aryloxy, cycloalkyl, cycloalkenyl or heterocyclic group; and R7 represents H or C1-C6 alkyl; or when taken together with the atom or atoms to which they are attached R6 and R7 form a monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula -(Z)n-(Alk)- or -(Alk)-(Z)n- wherein Z represents -0-, -S- or -NH-, Alk is as defined in relation to R6 and n is 0 or 1.

    IMMUNOMODULATING HETEROCYCLIC COMPOUNDS
    10.
    发明公开
    IMMUNOMODULATING HETEROCYCLIC COMPOUNDS 有权
    免疫调节杂环化合物

    公开(公告)号：EP1603917A1

    公开(公告)日：2005-12-14

    申请号：EP04719006.1

    申请日：2004-03-10

    申请人： Avidex Limited

    发明人： MATHEWS, Ian, Richard,Avidex Limited

    IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/5025 ,  A61P3/10 ,  A61P17/06 ,  A61P19/02 ,  A61P37/00

    CPC分类号： C07D487/04 ,  C07D519/00

    摘要： Compounds of formula (I) are inhibitors of CD80 and useful in immunomodulation therapy: wherein R1 and R3 independently represent H; F; CI; Br; -NO2; -CN; C1-C6 alkyl optionally substituted by F or Cl; or C1-C6 alkoxy optionally substituted by F; R4 represents a carboxylic acid group (-COOH) or an ester thereof, or -C(=O)NR6R7, -NR7C(=O)R6, -NR7C(=O)OR6, -NHC(=O)NR7R6 or -NHC(=S)NR7R6 wherein R6 represents H, or a radical of formula - (Alk)m-Q wherein m is 0 or 1, Alk is an optionally substituted divalent straight or branched C1-C12 alkylene, or C2-C12 alkenylene, or C2-C12 alkynylene radical or a divalent C3-C12 carbocyclic radical, any of which radicals may contain one or more -O-, -S- or -N(R8)- links wherein R8 represents H or C1-C4 alkyl, C3-­C4 alkenyl, C3-C4 alkynyl, or C3-C6 cycloalkyl, and Q represents H; -NR9R10 wherein R9 and R10 independently represents H; C1-C4 alkyl; C3-C4 alkenyl; C3-C4 alkynyl; C3-C6 cycloalkyl; an ester group; an optionally substituted carbocyclic or heterocyclic group; or R9 and R10 form a ring when taken together with the nitrogen to which they are attached, which ring is optionally substituted; and R7 represents H or C1-C6 alkyl; or when taken together with the atom or atoms to which they are attached R6 and R7 form an optionally substituted monocyclic heterocyclic ring having 5, 6 or 7 ring atoms; and X represents a bond or a divalent radical of formula - (Z)n-(Alk)- or - (Alk)-(Z)n- ­wherein Z represents -O-, -S- or -NH-, Alk is as defined in relation to R6 and n is 0 or 1.