发明公开
EP1562928A1 AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS
审中-公开
芳香族砜肟酸及其蛋白酶抑制剂的用途
- 专利标题： AROMATIC SULFONE HYDROXAMIC ACIDS AND THEIR USE AS PROTEASE INHIBITORS
- 专利标题（中）： 芳香族砜肟酸及其蛋白酶抑制剂的用途
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申请号： EP03783118.7申请日： 2003-11-03
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公开(公告)号： EP1562928A1公开(公告)日： 2005-08-17
- 发明人: AWASTHI, Alok, K. , BARTA, Thomas, E. , BECKER, Daniel, P. , BEDELL, Louis, J. , BOEHM, Terri, L. , CARROLL, Jeffery, N. , CHANDRAKUMAR, Nizal, S. , DECRESCENZO, Gary, A. , DESAI, Bipinchandra, N. , FOBIAN, Yvette, M. , FRESKOS, John, N. , HERON, Marcia, I. , HOCKERMAN, Susan, L. , JULL, Sara M. , KASSAB, Darren, J. , KOLODZIEJ, Stephen, A. , MCDONALD, Joseph, J. , MISCHKE, Deborah, A. , MULLINS, Patrick, B. , NORTON, Monica B. , RICO, Joseph G. , TALLEY, John J. , TRIVEDI, Mahima , VILLAMIL, Clara I. , WANG, Lijuan J.
- 申请人： Pharmacia Corporation
- 申请人地址： 700 Chesterfield Parkway West Chesterfield, MO 63017-1732 US
- 专利权人： Pharmacia Corporation
- 当前专利权人： Pharmacia Corporation
- 当前专利权人地址： 700 Chesterfield Parkway West Chesterfield, MO 63017-1732 US
- 代理机构： Albrecht, Thomas, Dr.
- 优先权： US291983 20021112
- 国际公布： WO2004043943 20040527
- 主分类号： C07D309/08
- IPC分类号： C07D309/08 ; C07D211/06 ; C07D405/12 ; C07D401/12 ; C07D407/12 ; C07D417/12 ; C07D413/12 ; C07D409/12 ; A61K31/4465 ; A61P25/00
摘要：
This invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
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