公开(公告)号：EP1562928A1

公开(公告)日：2005-08-17

申请号：EP03783118.7

申请日：2003-11-03

申请人： Pharmacia Corporation

发明人： AWASTHI, Alok, K. ,  BARTA, Thomas, E. ,  BECKER, Daniel, P. ,  BEDELL, Louis, J. ,  BOEHM, Terri, L. ,  CARROLL, Jeffery, N. ,  CHANDRAKUMAR, Nizal, S. ,  DECRESCENZO, Gary, A. ,  DESAI, Bipinchandra, N. ,  FOBIAN, Yvette, M. ,  FRESKOS, John, N. ,  HERON, Marcia, I. ,  HOCKERMAN, Susan, L. ,  JULL, Sara M. ,  KASSAB, Darren, J. ,  KOLODZIEJ, Stephen, A. ,  MCDONALD, Joseph, J. ,  MISCHKE, Deborah, A. ,  MULLINS, Patrick, B. ,  NORTON, Monica B. ,  RICO, Joseph G. ,  TALLEY, John J. ,  TRIVEDI, Mahima ,  VILLAMIL, Clara I. ,  WANG, Lijuan J.

IPC分类号： C07D309/08 ,  C07D211/06 ,  C07D405/12 ,  C07D401/12 ,  C07D407/12 ,  C07D417/12 ,  C07D413/12 ,  C07D409/12 ,  A61K31/4465 ,  A61P25/00

CPC分类号： C07D401/12 ,  A61K31/351 ,  A61K31/41 ,  A61K31/453 ,  A61K31/454 ,  C07D211/66 ,  C07D309/08 ,  C07D309/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04

摘要： This invention is directed to aromatic sulfone hydroxamic acids (including aromatic sulfone hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as 'matrix metalloprotease' or 'MMP') activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.

公开(公告)号：EP1385836A2

公开(公告)日：2004-02-04

申请号：EP02729204.4

申请日：2002-05-10

申请人： Pharmacia Corporation

发明人： BARTA, Thomas E. ,  BECKER, Daniel P. ,  BEDELL, Louis J. ,  BOEHM, Terri L. ,  FOBIAN, Yvette M. ,  FRESKOS, John N. ,  HOCKERMAN, Susan L. ,  KASSAB, Darren J. ,  KOLODZIEJ, Steve A. ,  MCDONALD, Joseph J. ,  NORTON, Monica B. ,  RICO, Joseph G. ,  TALLEY, John J. ,  VILLAMIL, Clara I. ,  WANG, Lijuan Jane ,  CARROLL, Jeffery, N. ,  DECRESCENZO, Gary, A. ,  MISCHKE, Deborah, A.

IPC分类号： C07D309/08 ,  C07D405/12 ,  C07D401/12 ,  C07D211/66 ,  C07D407/12 ,  C07D417/12 ,  C07D409/12 ,  C07D413/12 ,  A61K31/351 ,  A61P35/00

CPC分类号： C07D401/12 ,  A61K31/351 ,  A61K31/41 ,  A61K31/453 ,  A61K31/454 ,  C04B35/632 ,  C07D211/66 ,  C07D309/08 ,  C07D309/12 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04 ,  Y02A50/411

摘要： This invention is directed to aromatic sulfone hydroxamates (also known as "aromatic sulfone hydroxamic acids") and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as "matrix metalloprotease" or "MMP") activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.