发明公开
EP1565474A2 THIENO[3,2-B]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS
审中-公开
噻吩并[3,2-b]吡啶-6-甲腈和噻吩并[2,3-b]吡啶-5-腈作为蛋白激酶抑制剂
- 专利标题： THIENO[3,2-B]PYRIDINE-6-CARBONITRILES AND THIENO[2,3-B]PYRIDINE-5-CARBONITRILES AS PROTEIN KINASE INHIBITORS
- 专利标题（中）： 噻吩并[3,2-b]吡啶-6-甲腈和噻吩并[2,3-b]吡啶-5-腈作为蛋白激酶抑制剂
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申请号： EP03783385.2申请日： 2003-11-14
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公开(公告)号： EP1565474A2公开(公告)日： 2005-08-24
- 发明人: BOSCHELLI, Diane, Harris , ZHANG, Nan , BARRIOS SOSA, Ana, Carolina , DURUTLIC, Haris , WU, Biqi
- 申请人： Wyeth
- 申请人地址： Five Giralda Farms Madison, New Jersey 07940 US
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： Five Giralda Farms Madison, New Jersey 07940 US
- 代理机构： Wileman, David Francis
- 优先权： US428862P 20021125
- 国际公布： WO2004048386 20040610
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/4365 ; A61P35/00 ; A61P9/10 ; A61P19/10 ; A61P13/12
摘要：
This invention provides compounds of Formula (1 a) - (1f) wherein:X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.
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