公开(公告)号：EP1680425B1

公开(公告)日：2007-01-10

申请号：EP04788820.1

申请日：2004-09-17

申请人： Wyeth Holdings Corporation

发明人： ZHANG, Nan ,  AYRAL-KALOUSTIAN, Semiramis ,  NGUYEN, Thai, Hiep ,  WU, Yanzhong ,  TONG, Wei

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P35/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

公开(公告)号：EP1242382B1

公开(公告)日：2007-02-07

申请号：EP00988437.0

申请日：2000-12-29

申请人： Wyeth

发明人： BERGER, Dan, M. ,  DUTIA, Minu, D. ,  DEMORIN, Frenel, F. ,  BOSCHELLI, Diane, H. ,  POWELL, Dennis, W. ,  TSOU, Hwei-Ru ,  WISSNER, Allan ,  ZHANG, Nan ,  YE, Fei ,  WU, Biqi

IPC分类号： C07D215/54 ,  C07D471/04 ,  C07D513/04 ,  C07D495/04 ,  C07D491/04 ,  A61K31/435 ,  A61K31/4353 ,  A61P35/00

CPC分类号： C07D471/04 ,  C07D215/54 ,  C07D491/04 ,  C07D495/04 ,  C07D513/04

摘要： This invention provides compounds of formula (1) which are useful as inhibitors of protein tyrosine kinase and are antiproliferative agents.

公开(公告)号：EP1680425A1

公开(公告)日：2006-07-19

申请号：EP04788820.1

申请日：2004-09-17

申请人： Wyeth Holdings Corporation

发明人： ZHANG, Nan ,  AYRAL-KALOUSTIAN, Semiramis ,  NGUYEN, Thai, Hiep ,  WU, Yanzhong ,  TONG, Wei

IPC分类号： C07D487/04 ,  A61P35/00 ,  A61P35/04 ,  A61K31/519 ,  C07D249/00 ,  C07D239/00

CPC分类号： C07D487/04

摘要： This invention relates to certain 6-[(substituted)phenyl]triazolopyrimidine compounds or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof. The present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

公开(公告)号：EP1663241A1

公开(公告)日：2006-06-07

申请号：EP04784529.2

申请日：2004-09-17

申请人： Wyeth Holdings Corporation

发明人： ZHANG, Nan ,  AYRAL-KALOUSTIAN, Semiramis ,  NGUYEN, Thai, Hiep

IPC分类号： A61K31/505 ,  A61K31/506 ,  A61P35/00 ,  C07D239/42 ,  C07D239/48

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

摘要： This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

公开(公告)号：EP1565474A2

公开(公告)日：2005-08-24

申请号：EP03783385.2

申请日：2003-11-14

申请人： Wyeth

发明人： BOSCHELLI, Diane, Harris ,  ZHANG, Nan ,  BARRIOS SOSA, Ana, Carolina ,  DURUTLIC, Haris ,  WU, Biqi

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P35/00 ,  A61P9/10 ,  A61P19/10 ,  A61P13/12

CPC分类号： C07D495/04

摘要： This invention provides compounds of Formula (1 a) - (1f) wherein:X, R1, and R2 are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection and process for producing said compounds.

公开(公告)号：EP1268431A1

公开(公告)日：2003-01-02

申请号：EP01924407.8

申请日：2001-03-28

申请人： Wyeth

发明人： BOSCHELLI, Diane, Harris ,  WANG, Yanong ,  BOSCHELLI, Frank, Charles ,  BERGER, Dan, Maarten ,  ZHANG, Nan ,  POWELL, Dennis, William ,  YE, Fei ,  YAMASHITA, Ayako ,  DEMORIN, Frenel, Fils ,  WU, Biqi ,  TSOU, Hwei-Ru ,  OVERBEEK-KLUMPERS, Elsebe, Geraldine ,  WISSNER, Allan

IPC分类号： C07D215/54 ,  C07D409/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D401/12 ,  C07D401/10 ,  C07D401/14 ,  C07D405/12 ,  C07D471/04 ,  A61K31/4706 ,  A61K31/4709 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D215/54 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D471/04

摘要： Compounds of Formula (I), having the structure or a pharmaceutically salt thereof are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

公开(公告)号：EP1268431B1

公开(公告)日：2007-08-29

申请号：EP01924407.8

申请日：2001-03-28

申请人： Wyeth

发明人： BOSCHELLI, Diane, Harris ,  WANG, Yanong ,  BOSCHELLI, Frank, Charles ,  BERGER, Dan, Maarten ,  ZHANG, Nan ,  POWELL, Dennis, William ,  YE, Fei ,  YAMASHITA, Ayako ,  DEMORIN, Frenel, Fils ,  WU, Biqi ,  TSOU, Hwei-Ru ,  OVERBEEK-KLUMPERS, Elsebe, Geraldine ,  WISSNER, Allan

IPC分类号： C07D215/54 ,  C07D409/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D401/12 ,  C07D401/10 ,  C07D401/14 ,  C07D405/12 ,  C07D471/04 ,  A61K31/4706 ,  A61K31/4709 ,  A61P35/00 ,  C07D221/00

CPC分类号： C07D401/04 ,  C07D215/54 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D471/04

摘要： Compounds of Formula (I), having the structure or a pharmaceutically salt thereof are useful as antineoplastic agents and in the treatment of osteoporosis and polycystic kidney disease.

公开(公告)号：EP1684763A1

公开(公告)日：2006-08-02

申请号：EP04784454.3

申请日：2004-09-17

申请人： Wyeth Holdings Corporation

发明人： ZHANG, Nan ,  AYRAL-KALOUSTIAN, Semiramis

IPC分类号： A61K31/519 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04

摘要： This invention relates to certain 6-aryl-7-halo-imidazo[1,2-a]pyrimidines or pharmaceutically acceptable salts thereof, and compositions containing said compounds or pharmaceutically acceptable salts thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals by promotion of microtubule polymerization. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or pharmaceutically acceptable salts thereof.

公开(公告)号：EP1663241B1

公开(公告)日：2009-05-27

申请号：EP04784529.2

申请日：2004-09-17

申请人： Wyeth Holdings Corporation

发明人： ZHANG, Nan ,  AYRAL-KALOUSTIAN, Semiramis ,  NGUYEN, Thai, Hiep

IPC分类号： A61K31/505 ,  A61K31/506 ,  A61P35/00 ,  C07D239/42 ,  C07D239/48

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

摘要： This invention relates to certain 5-arylpyrimidine compounds or a pharmaceutically acceptable salt thereof, and compositions containing said compounds or a pharmaceutically acceptable salt thereof, wherein said compounds are anti-cancer agents useful for the treatment of cancer in mammals. This invention further relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal and further provides a method for the treatment or prevention of cancerous tumors that express multiple drug resistance (MDR) or are resistant because of MDR, in a mammal in need thereof which method comprises administering to said mammal an effective amount of said compounds or a pharmaceutically acceptable salt thereof. More specifically, the present invention relates to a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by promotion of microtubule polymerization which comprises administering to said mammal an effective amount of said compounds and pharmaceutically acceptable salts thereof.

公开(公告)号：EP1756117A2

公开(公告)日：2007-02-28

申请号：EP05742281.8

申请日：2005-05-10

申请人： Wyeth

发明人： BOSCHELLI, Diane, Harris ,  ZHANG, Nan ,  BARRIOS SOSA, Ana, Carolina ,  DURUTLIC, Haris ,  WU, Biqi

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  A61K31/44 ,  A61K31/497 ,  A61K31/535

摘要： This invention provides compounds of Formula II: wherein: R1, R2 and X are defined hereinbefore in the specification, which are useful in the treatment of cancer, stroke, myocardial infarction, neuropathic pain, osteoporosis, polycystic kidney disease, autoimmune disease, rheumatoid arthritis, and transplant rejection. The invention also provides processes for producing said compounds.