发明公开
- 专利标题： HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
- 专利标题（中）： 高效的siRNA降低靶基因的表达
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申请号： EP03708928.1申请日： 2003-01-31
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公开(公告)号： EP1572902A2公开(公告)日： 2005-09-14
- 发明人: BROWN, David , FORD, Lance, P. , JARVIS, Rich , PALLOTTA, Vince , PASLOSKE, Brittan
- 申请人： AMBION, INC.
- 申请人地址： 2130 Woodward Street, No. 200 Austin, TX 78744-1832 US
- 专利权人： AMBION, INC.
- 当前专利权人： AMBION, INC.
- 当前专利权人地址： 2130 Woodward Street, No. 200 Austin, TX 78744-1832 US
- 代理机构： Sonn & Partner Patentanwälte
- 优先权： US353332P 20020201
- 国际公布： WO2003064621 20030807
- 主分类号： C12N1/00
- IPC分类号： C12N1/00
摘要：
The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.
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