公开(公告)号：EP1572902A3

公开(公告)日：2005-10-12

申请号：EP03708928.1

申请日：2003-01-31

申请人： AMBION, INC.

发明人： BROWN, David ,  FORD, Lance, P. ,  JARVIS, Rich ,  PALLOTTA, Vince ,  PASLOSKE, Brittan

IPC分类号： C12N1/00

公开(公告)号：EP1572902A2

公开(公告)日：2005-09-14

申请号：EP03708928.1

申请日：2003-01-31

申请人： AMBION, INC.

发明人： BROWN, David ,  FORD, Lance, P. ,  JARVIS, Rich ,  PALLOTTA, Vince ,  PASLOSKE, Brittan

IPC分类号： C12N1/00

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1137 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/322 ,  C12N2310/333 ,  C12N2310/334 ,  C12N2310/335 ,  C12N2310/336 ,  C12N2310/53 ,  C12N2320/50 ,  C12Y102/01012

摘要： The present invention provides improved methods of attenuating gene expression through the phenomenon of RNA interference. The invention provides methods of synthesis of double stranded RNAs (dsRNAs) of increased potency for use as small interfering RNA (siRNA). Surprisingly and unexpectedly, siRNAs made by the methods of the invention are significantly more potent than previously available siRNAs.