发明公开
EP1578765A2 SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION
审中-公开
糖代用品遏制和组合物的用途在DERGENMODULATION低聚物化合物
- 专利标题： SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION
- 专利标题（中）： 糖代用品遏制和组合物的用途在DERGENMODULATION低聚物化合物
-
申请号： EP03783131.0申请日： 2003-11-04
-
公开(公告)号： EP1578765A2公开(公告)日： 2005-09-28
- 发明人: BAKER, Brenda, F. , ELDRUP, Anne, B. , MANOHARAN, Muthiah , BHAT, Balkrishen , GRIFFEY, Richard , SWAYZE, Eric, E. , CROOKE, Stanley, T.
- 申请人： ISIS PHARMACEUTICALS, INC.
- 申请人地址： 1896 Rutherford Road Carlsbad, CA 92008 US
- 专利权人： ISIS PHARMACEUTICALS, INC.
- 当前专利权人： ISIS PHARMACEUTICALS, INC.
- 当前专利权人地址： 1896 Rutherford Road Carlsbad, CA 92008 US
- 代理机构： Hallybone, Huw George
- 优先权： US423760P 20021105
- 国际公布： WO2004043979 20040527
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a sugar surrogate modification.
信息查询
