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公开(公告)号：EP1060270A1
公开(公告)日：2000-12-20
申请号：EP99911036.4
申请日：1999-03-02
CPC分类号： C12Q1/6816 , B01J2219/00702 , B01J2219/00722 , C12Q1/6806 , C12Q1/6811 , C40B40/06 , H01J49/004 , Y10T436/24 , C12Q2565/627 , C12Q2525/101 , C12Q2565/133 , C12Q2525/121 , C12Q2565/607
摘要： The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified. In preferred embodiments, such identification can be made simultaneously with libraries of ligands.
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公开(公告)号：EP1560839A2
公开(公告)日：2005-08-10
申请号：EP03781746.7
申请日：2003-11-04
发明人： BAKER, Brenda, F. , ELDRUP, Anne, B. , MANOHARAN, Muthiah , BHAT, Balkrishen , GRIFFEY, Richard , SWAYZE, Eric, E. , CROOKE, Stanley, T.
IPC分类号： C07H21/02
CPC分类号： C12N15/1135 , C07H21/02 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2320/51 , C12Y301/03048 , C12N2310/3525 , C12N2310/3521
摘要： Oligomer compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capble of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes at least one nucleotide comprising a chimeric organic composition. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide comprising a chimeric organic composition.
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3.发明公开
公开(公告)号：EP1169111A1
公开(公告)日：2002-01-09
申请号：EP00903344.0
申请日：2000-01-19
CPC分类号： H01J49/0059 , Y10T436/143333 , Y10T436/24
摘要： The present invention discloses novel methods and apparatuses for mass spectrometry. In the methods and apparatuses of the invention, ions are accumulated in an ion reservoir and dissociated with coherent radiation prior to mass analysis. These methods and apparatuses are amenable to mass spectrometric analysis of biomolecules and are particularly useful for the sequencing of oligonucleotides, peptides and oligosaccharides.
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4.发明授权POLYCYCLIC SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION 有权多环芳烃SUGAR SPARE LEG AMUSING低聚物化合物和组合物用于基因调节
公开(公告)号：EP1562971B1
公开(公告)日：2014-02-12
申请号：EP03768647.4
申请日：2003-11-04
发明人： ALLERSON, Charles , BHAT, Balkrishen , ELDRUP, Ann, B. , MANOHARAN, Muthiah , GRIFFEY, Richard , BAKER, Brenda, F. , SWAYZE, Eric, E.
CPC分类号： C12N15/1135 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2310/53
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5.发明公开DOUBLE STRAND COMPOSITIONS COMPRISING DIFFERENTIALLY MODIFIED STRANDS FOR USE IN GENE MODULATION 审中-公开有使用的基因调节其他的变形STRANDS双组份
公开(公告)号：EP1766071A2
公开(公告)日：2007-03-28
申请号：EP05757763.7
申请日：2005-06-02
发明人： BHAT, Balkrishen , PRAKASH, Thazha, P. , DANDE, Prasad , ALLERSON, Charles , GRIFFEY, Richard , SWAYZE, Eric E.
CPC分类号： C12N15/113 , C07H21/02 , C12N15/111 , C12N2310/14 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2320/51 , C12N2310/3521
摘要： The present invention provides douse stranded compositions wherein each strand is modified to have a motif defined by positioning of ß-D-ribonucleosides and sugar modified nucleosides. More particularly, the present compositions comprise one strand having a gapped motif and another strand having a gapped motif, a hemimer motif, a blockmer motif, a fully modified motif, a positionally modified motif or an alternating motif. At least one of the strands has complementarity to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In some embodiments, the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
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6.发明公开SUGAR SURROGATE-CONTAINING OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATION 审中-公开糖代用品遏制和组合物的用途在DERGENMODULATION低聚物化合物
公开(公告)号：EP1578765A2
公开(公告)日：2005-09-28
申请号：EP03783131.0
申请日：2003-11-04
发明人： BAKER, Brenda, F. , ELDRUP, Anne, B. , MANOHARAN, Muthiah , BHAT, Balkrishen , GRIFFEY, Richard , SWAYZE, Eric, E. , CROOKE, Stanley, T.
IPC分类号： C07H21/04
CPC分类号： C07H21/00 , C07H21/04 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/343 , C12N2310/3521 , C12N2310/3533 , C12N2320/51
摘要： Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a sugar surrogate modification.
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7.发明公开2'-SUBSTITUTED OLIGOMERIC COMPOUNDS AND COMPOSITIONS FOR USE IN GENE MODULATIONS 审中-公开2'-取代低聚物化合物和组合FOR USE IN GENMODULATIONEN
公开(公告)号：EP1563070A2
公开(公告)日：2005-08-17
申请号：EP03786574.8
申请日：2003-11-04
发明人： BAKER, Brenda , ELDRUP, Anne B. , MANOHARAN, Muthiah , BHAT, Balkrishen , GRIFFEY, Richard , SWAYZE, Eric, E. , CROOKE, Stanely, T. , PRAKASH, Thazha, P.
CPC分类号： C12N15/1135 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/53 , C12N2310/3521
摘要： Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modified sugar and/or backbone modification. In some embodiments the modification is a 2' substituent group on a sugar moiety that is not H or OH. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleotide of the oligomer has a modified sugar and/or backbone modification.
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公开(公告)号：EP1127312A1
公开(公告)日：2001-08-29
申请号：EP99921921.5
申请日：1999-05-12
发明人： GRIFFEY, Richard , SWAYZE, Eric
IPC分类号： G06F9/455
摘要： Methods for the computer-generation of virtual libraries of compounds are disclosed, including methods for tracking the addition of fragments, use of reagents, and the transformations performed. A tracking table is generated for sample compound C1 and includes entries: (a) listing the order of fragments used, and (b) listing the transformations performed for each synthesis path.
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公开(公告)号：EP0656790A1
公开(公告)日：1995-06-14
申请号：EP93907292.0
申请日：1993-03-05
发明人： COOK, Phillip Dan , BRUICE, Thomas , GUINOSSO, Charles John , KAWASAKI, Andrew Mamoru , GRIFFEY, Richard
IPC分类号： A61K31 , A61K48 , A61P31 , A61P43 , C07H19 , C07H21 , C07H23 , C07J43 , C07K14 , C12N9 , C12N15 , C12P21 , C12Q1 , A61K38
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N9/0069 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322 , C12Q1/68 , C12Q1/6813 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
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10.发明授权
公开(公告)号：EP1083980B1
公开(公告)日：2007-03-21
申请号：EP99924185.4
申请日：1999-05-12
发明人： ECKER, David, J. , GRIFFEY, Richard , CROOKE, Stanely, T. , SAMPATH, Ranga , SWAYZE, Eric , MOHAN, Venkatraman , HOFSTADLER, Steven , MCNEIL, John
IPC分类号： C12N15/11 , C12Q1/68 , C12P19/34 , G06F15/18 , G06F17/50 , G01N31/00 , G01N33/53 , G01N33/543 , G01N33/566 , C12N15/10 , C07K1/04 , G01N33/68 , B01J19/00
CPC分类号： G01N33/6848 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00313 , B01J2219/00351 , B01J2219/00585 , B01J2219/0059 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , C07K1/047 , C12N15/1048 , C12N15/113 , C12Q1/6811 , C40B60/14 , G01N33/68 , G01N33/6851
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