发明公开
EP1585735A1 HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS
审中-公开
HYDROXAMIDSÄUREDERIVATEALS组蛋白去乙酰化酶（HDAC）抑制剂
- 专利标题： HYDROXAMID ACID DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS
- 专利标题（中）： HYDROXAMIDSÄUREDERIVATEALS组蛋白去乙酰化酶（HDAC）抑制剂
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申请号： EP04701698.5申请日： 2004-01-13
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公开(公告)号： EP1585735A1公开(公告)日： 2005-10-19
- 发明人: URANO, YasuharuFujisawa Pharmaceutical Co., Ltd. , SATOH, ShigekiFujisawa Pharmaceutical Co., Ltd. , ISHIBASHI, NaokiFujisawa Pharmaceutical Co., Ltd. , KAMIJO, KazunoriFujisawa Pharmaceutical Co., Ltd.
- 申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 申请人地址： 4-7, Doshomachi 3-chome, Chuo-ku Osaka-shi,Osaka-fu 541-8514 JP
- 专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 4-7, Doshomachi 3-chome, Chuo-ku Osaka-shi,Osaka-fu 541-8514 JP
- 代理机构： Gille Hrabal Struck Neidlein Prop Roos
- 优先权： AU2003900116 20030113; AU2003905406 20031006
- 国际公布： WO2004063169 20040729
- 主分类号： C07D235/16
- IPC分类号： C07D235/16 ; C07D471/04 ; C07D487/04 ; C07D235/12 ; C07D491/04 ; C07D401/04 ; C07D403/04 ; C07D233/64 ; C07D233/90 ; C07D233/68 ; A61K31/4184 ; A61K31/4164 ; A61K31/4178 ; A61P35/00
摘要：
A compound having the following formula (I): wherein R1 is N-containing heterocyclic ring optionally substituted with one or more suitable substituent(s), R2 is hydroxyamino, R3 is hydrogen or a suitable substituent, L1 is -(CH?2#191)?n#191- (wherein n is an integer of 0 to 6) optionally substituted with one or more suitable substituent(s), wherein one or more methylene(s) may be replaced with suitable heteroatom(s), and L2 is lower alkenylene, or a salt thereof. The compound is useful as a histone deacetylase inhibitor.
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