发明公开
EP1598367A1 Modified coagulation factors with enhanced stability and their derivatives
审中-公开
Modifizierte Gerinnungsfaktoren miterhöhterStabilitätund deren Derivate
- 专利标题： Modified coagulation factors with enhanced stability and their derivatives
- 专利标题（中）： Modifizierte Gerinnungsfaktoren miterhöhterStabilitätund deren Derivate
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申请号： EP04011736.8申请日： 2004-05-18
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公开(公告)号： EP1598367A1公开(公告)日： 2005-11-23
- 发明人: Weimer, Thomas, Dr. , Schulte, Stefan, Dr. , Hofmann, Kay, Dr. , Hauser, Hans-Peter, Dr.
- 申请人： ZLB Behring GmbH
- 申请人地址： Emil-von-Behring-Strasse 76 35041 Marburg DE
- 专利权人： ZLB Behring GmbH
- 当前专利权人： ZLB Behring GmbH
- 当前专利权人地址： Emil-von-Behring-Strasse 76 35041 Marburg DE
- 主分类号： C07K14/745
- IPC分类号： C07K14/745 ; C07K14/755 ; C12N15/12
摘要：
The present invention relates to modified nucleic acid sequences coding for coagulation Factors, in particular human FV and human Factor VIII and their derivatives with improved stability, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises modified DNA sequences.
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