发明公开
- 专利标题： TETRACYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
- 专利标题（中）： 四环吡衍生物作为激酶抑制剂，制造工艺和制药用
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申请号： EP04707538.7申请日： 2004-02-03
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公开(公告)号： EP1599202A1公开(公告)日： 2005-11-30
- 发明人: VANOTTI, Ermes , CERVI, Giovanni , PULICI, Maurizio , MENICHINCHERI, Maria , VARASI, Mario , VIANELLO, Paola , Ferguson, Ron.
- 申请人： Pharmacia Italia S.p.A.
- 申请人地址： Via Robert Koch 1.2 20152 Milano IT
- 专利权人： Pharmacia Italia S.p.A.
- 当前专利权人： Pharmacia Italia S.p.A.
- 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
- 代理机构： Modiano, Micaela Nadia
- 优先权： US448049P 20030217
- 国际公布： WO2004071507 20040826
- 主分类号： A61K31/4162
- IPC分类号： A61K31/4162 ; C07D487/04 ; C07D209/82 ; A61P25/00 ; A61P35/00 ; A61P37/00
摘要：
The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a tetracyclic pyrazole. The invention also provides specific tetracyclic pyrazole derivatives, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
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