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1.发明公开FUSED OXABICYCLIC AMINOALCOHOLS AS NEW SCAFFOLDS FOR COMBINATORIAL LIBRARIES 审中-公开简明oxabicyclic氨基醇AS新塔用于组合特定的库
公开(公告)号：EP1615933A2
公开(公告)日：2006-01-18
申请号：EP04741435.4
申请日：2004-03-23
IPC分类号： C07D493/04 , A61P35/00
CPC分类号： C07H7/00
摘要： Fused oxabicyclic aminoalcohols of formula (I) and (II) processes for their preparation and uses thereof as scaffolds for preparing libraries of compounds of formula (XXVII) and (XXVIII) wherein the meanings of RI, R2,R3,R4 and R5 are reported in the specification, are described.
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2.发明公开
公开(公告)号：EP1599202A1
公开(公告)日：2005-11-30
申请号：EP04707538.7
申请日：2004-02-03
发明人： VANOTTI, Ermes , CERVI, Giovanni , PULICI, Maurizio , MENICHINCHERI, Maria , VARASI, Mario , VIANELLO, Paola , Ferguson, Ron.
IPC分类号： A61K31/4162 , C07D487/04 , C07D209/82 , A61P25/00 , A61P35/00 , A61P37/00
CPC分类号： C07D487/04 , A61K31/4162 , A61K45/06 , A61K2300/00
摘要： The present invention provides a method for treating diseases caused by and/or associated with an altered protein kinase activity which comprises administering to a mammal in need thereof an effective amount of a tetracyclic pyrazole. The invention also provides specific tetracyclic pyrazole derivatives, useful intermediates, a library comprising at least two of them, a process for their preparation and the pharmaceutical compositions containing them, which are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.
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