发明公开
- 专利标题: GROUP 1 MITE POLYPEPTIDE VARIANTS
- 专利标题(中): VARIANTE DES TYP 1 MILBEPOLYPEPTIDS
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申请号: EP04729048.1申请日: 2004-04-23
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公开(公告)号: EP1620461A2公开(公告)日: 2006-02-01
- 发明人: SONI, Nanna, Kristensen , FRIIS, Esben, Peter , ROGGEN, Erwin, Ludo , LYNGSTRAND, Stina, Thulesen
- 申请人: Novozymes A/S
- 申请人地址: Krogshoejvej 36 2880 Bagsvaerd DK
- 专利权人: Novozymes A/S
- 当前专利权人: Novozymes A/S
- 当前专利权人地址: Krogshoejvej 36 2880 Bagsvaerd DK
- 优先权: DK200300628 20030425; DK200301093 20030721
- 国际公布: WO2004096844 20041111
- 主分类号: C07K14/435
- IPC分类号: C07K14/435 ; C12N15/12 ; A61K38/17 ; A61K39/35
摘要:
This invention concerns variants of group 1 mite polypeptides, wherein the mature polypeptide of the variant comprise one or more mutations in the positions or corresponding to the positions consisting of A10, A12, E13, G29, G30, G32, A46, Y47, S54, L55, D64, A66, S67, G73, T75, I80, Q84, N86, G87, S92, Y93, Y96, A98, R99, E100, Q101, R104, R105, P106, Q109, R110, F111, G112, I113, A132, I144, K145, D146, D148, R151, I158, I159, Q160, R161, D162, N163, G164, Y165, Q166, N179, A180, G182, V183, D184, A205, I208 of SEQ ID NO: 1 or 10, 12, 13, 29, 30, 32, 46, 47, 54, 55, 64, 66, 67, 73, 75, I80, 84, 86, 87, 92, Y93, 96, 98, 99, 100, 101, 104, 105, 106, 109, 110, 111, 112, 113, 132, 144, 145, 146, 148, 151, 158, 159, 160, 161, 162, 163, 164, 165, 166, 179, 180, 182, 183, 184, 205, 208 of the mature Der p 1 polypeptide.
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