发明公开
EP1622934A2 TRUNCATED FORMS OF HUMAN DBF4, COMPLEXES WITH THEIR INTERACTING PARTNERS AND METHODS FOR IDENTIFICATION OF INHIBITORS THEREOF
审中-公开
人类DBF4缩短的形式，随着对鉴定及其抑制剂你的相互作用伴侣和方法复杂
- 专利标题： TRUNCATED FORMS OF HUMAN DBF4, COMPLEXES WITH THEIR INTERACTING PARTNERS AND METHODS FOR IDENTIFICATION OF INHIBITORS THEREOF
- 专利标题（中）： 人类DBF4缩短的形式，随着对鉴定及其抑制剂你的相互作用伴侣和方法复杂
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申请号： EP04728359.3申请日： 2004-04-20
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公开(公告)号： EP1622934A2公开(公告)日： 2006-02-08
- 发明人: VALSASINA, Barbara , CRISTIANI, Cinzia , KNAPP, Stefan , THIEFFINE, Sandrine , PEREGO, Rita , SACCARDO, Maria Beatrice , KALISZ, Henryk
- 申请人： Pharmacia Italia S.p.A. , Valsasina, Barbara
- 申请人地址： Via Robert Koch 1.2 20152 Milano IT
- 专利权人： Pharmacia Italia S.p.A.,Valsasina, Barbara
- 当前专利权人： Pharmacia Italia S.p.A.,Valsasina, Barbara
- 当前专利权人地址： Via Robert Koch 1.2 20152 Milano IT
- 代理机构： Modiano, Micaela Nadia
- 优先权： US467956P 20030505
- 国际公布： WO2004099243 20041118
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C12N15/12
摘要：
The present invention generally relates to the desing, expression and purification of truncated forms of the human dbf4 protein, optionally in complexe with dbf4 interacting partners, such as human cdc7, and its use in the discovery, indentification and characterization of inhibitors of the components of the complex, either when associated or when present as uncomplexed proteins in situ or in vitro. More specifically, the present invention relates to the utilization of specific truncated forms of human dbf4 for the production of an active, non-aggregated, monodispersed hetorodimer of human dbf4 complexed to human cdc7, or other protein interactors.
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