专利检索 ap:"Valsasina, Barbara" 第 1 页

1.

发明公开
TRUNCATED FORMS OF HUMAN DBF4, COMPLEXES WITH THEIR INTERACTING PARTNERS AND METHODS FOR IDENTIFICATION OF INHIBITORS THEREOF 审中-公开
标题翻译：人类DBF4缩短的形式，随着对鉴定及其抑制剂你的相互作用伴侣和方法复杂

公开(公告)号：EP1622934A2

公开(公告)日：2006-02-08

申请号：EP04728359.3

申请日：2004-04-20

申请人： Pharmacia Italia S.p.A. , Valsasina, Barbara

发明人： VALSASINA, Barbara , CRISTIANI, Cinzia , KNAPP, Stefan , THIEFFINE, Sandrine , PEREGO, Rita , SACCARDO, Maria Beatrice , KALISZ, Henryk

IPC分类号： C07K14/47 , C12N15/12

CPC分类号： C07K14/4738

摘要： The present invention generally relates to the desing, expression and purification of truncated forms of the human dbf4 protein, optionally in complexe with dbf4 interacting partners, such as human cdc7, and its use in the discovery, indentification and characterization of inhibitors of the components of the complex, either when associated or when present as uncomplexed proteins in situ or in vitro. More specifically, the present invention relates to the utilization of specific truncated forms of human dbf4 for the production of an active, non-aggregated, monodispersed hetorodimer of human dbf4 complexed to human cdc7, or other protein interactors.