发明授权
EP1644342B1 Arylpyrimidines useful for the treatment of sex hormone-related conditions such as endometriosis, prostate cancer and the like
有权
适合的性激素相关的病症，例如子宫内膜异位症，前列腺癌等的治疗芳基嘧啶
- 专利标题： Arylpyrimidines useful for the treatment of sex hormone-related conditions such as endometriosis, prostate cancer and the like
- 专利标题（中）： 适合的性激素相关的病症，例如子宫内膜异位症，前列腺癌等的治疗芳基嘧啶
-
申请号： EP04756667.4申请日： 2004-07-06
-
公开(公告)号： EP1644342B1公开(公告)日： 2012-05-09
- 发明人: HUANG, Charles, Q. , CHEN, Chen , CHEN, Yongsheng , GUO, Zhiqiang , WADE, Warren , ROWBOTTOM, Martin , RUETER, Jaimie, K.
- 申请人： NEUROCRINE BIOSCIENCES, INC.
- 申请人地址： 12790 El Camino Real San Diego, CA 92130-1102 US
- 专利权人： NEUROCRINE BIOSCIENCES, INC.
- 当前专利权人： NEUROCRINE BIOSCIENCES, INC.
- 当前专利权人地址： 12790 El Camino Real San Diego, CA 92130-1102 US
- 代理机构： Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权： US485424P 20030707
- 国际公布： WO2005007633 20050127
- 主分类号： C07D239/54
- IPC分类号： C07D239/54 ; C07D403/12 ; A61K31/513 ; A61P5/06 ; C07D241/00 ; C07D239/00 ; C07D207/00
摘要：
GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
公开/授权文献
信息查询
