-
1.发明授权GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO 有权促性腺激素释放激素受体的拮抗剂及任何相关手续
公开(公告)号：EP2155194B1
公开(公告)日：2015-01-21
申请号：EP08745136.5
申请日：2008-04-04
发明人： BEATON, Graham , CHEN, Mi , COON, Timothy, Richard , EWING, Todd , JIANG, Wanlong , LOWE, Richard , MOREE, Willy , HARRIOTT, Nicole , WADE, Warren , ZHAO, Liren , ZHU, Yun-Fei , ROWBOTTOM, Martin , ASHWEEK, Neil
IPC分类号： A61K31/435 , A61P35/00 , C07C233/88 , C07C255/57 , C07D213/56 , C07D213/61 , C07D213/70 , C07D213/84 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/12 , C07D413/12 , C07D417/12 , C07D495/02
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
-
2.发明公开PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS 有权嘧啶-2,4-二酮衍生物促性腺激素释放激素受体拮抗剂
公开(公告)号：EP1646389A1
公开(公告)日：2006-04-19
申请号：EP04777603.4
申请日：2004-07-06
发明人： GUO, Zhiqiang , CHEN, Yongsheng , WU, Dongpei , CHEN, Chen , WADE, Warren , DWIGHT, Wesley, J. , HUANG, Charles, Q. , TUCCI, Fabio, C.
IPC分类号： A61K31/513 , C07D239/54 , C07D401/12 , C07D405/04 , A61P5/02
CPC分类号： C07D239/54 , C07D239/52 , C07D403/12 , C07D405/04
摘要： GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
-
3.发明公开GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO 有权适合的性激素相关的病症，例如子宫内膜异位症，前列腺癌等的治疗芳基嘧啶
公开(公告)号：EP1644342A1
公开(公告)日：2006-04-12
申请号：EP04756667.4
申请日：2004-07-06
发明人： HUANG, Charles, Q. , CHEN, Chen , CHEN, Yongsheng , GUO, Zhiqiang , WADE, Warren , ROWBOTTOM, Martin , RUETER, Jaimie, K.
IPC分类号： C07D239/54 , C07D403/12 , A61K31/513 , A61P5/06 , C07D241/00 , C07D239/00 , C07D207/00
CPC分类号： C07D239/54 , C07D403/12
摘要： GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
-
4.发明授权Arylpyrimidines useful for the treatment of sex hormone-related conditions such as endometriosis, prostate cancer and the like 有权适合的性激素相关的病症，例如子宫内膜异位症，前列腺癌等的治疗芳基嘧啶
公开(公告)号：EP1644342B1
公开(公告)日：2012-05-09
申请号：EP04756667.4
申请日：2004-07-06
发明人： HUANG, Charles, Q. , CHEN, Chen , CHEN, Yongsheng , GUO, Zhiqiang , WADE, Warren , ROWBOTTOM, Martin , RUETER, Jaimie, K.
IPC分类号： C07D239/54 , C07D403/12 , A61K31/513 , A61P5/06 , C07D241/00 , C07D239/00 , C07D207/00
CPC分类号： C07D239/54 , C07D403/12
摘要： GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
-
5.发明公开GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO 有权促性腺激素释放激素受体的拮抗剂及任何相关手续
公开(公告)号：EP2155194A1
公开(公告)日：2010-02-24
申请号：EP08745136.5
申请日：2008-04-04
发明人： BEATON, Graham , CHEN, Mi , COON, Timothy, Richard , EWING, Todd , JIANG, Wanlong , LOWE, Richard , MOREE, Willy , SMITH, Nicole , WADE, Warren , ZHAO, Liren , ZHU, Yun-Fei , ROWBOTTOM, Martin , ASHWEEK, Neil
IPC分类号： A61K31/435 , A61P35/00 , C07C233/88 , C07C255/57 , C07D213/56 , C07D213/61 , C07D213/70 , C07D213/84 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/12 , C07D413/12 , C07D417/12 , C07D495/02
CPC分类号： C07D495/04 , C07C233/88 , C07C235/42 , C07C255/57 , C07D213/56 , C07D213/58 , C07D213/61 , C07D213/64 , C07D213/70 , C07D213/81 , C07D213/84 , C07D213/89 , C07D215/14 , C07D215/54 , C07D239/36 , C07D401/04 , C07D401/12 , C07D413/12 , C07D417/12
摘要： GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R1a, R1b, R1c, R1d, R2, R2a, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
-
6.发明授权PYRIMIDINE-2,4-DIONE DERIVATIVES AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS 有权嘧啶-2,4-二酮衍生物促性腺激素释放激素受体拮抗剂
公开(公告)号：EP1646389B1
公开(公告)日：2008-09-10
申请号：EP04777603.4
申请日：2004-07-06
发明人： GUO, Zhiqiang , CHEN, Yongsheng , WU, Dongpei , CHEN, Chen , WADE, Warren , DWIGHT, Wesley, J. , HUANG, Charles, Q. , TUCCI, Fabio, C.
IPC分类号： A61K31/513 , C07D239/54 , C07D401/12 , C07D405/04 , A61P5/02
CPC分类号： C07D239/54 , C07D239/52 , C07D403/12 , C07D405/04
摘要： GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R1a, R1b, R1c, R2a, R2b, R3, R4, R5, R6 and X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.015 秒)
