发明公开
- 专利标题： PROCESS AND INTERMEDIATES FOR SYNTHESIS ENTECAVIR
- 专利标题（中）： 方法和中间体合成恩替卡韦
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申请号： EP03812974申请日： 2003-12-10
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公开(公告)号： EP1644384A4公开(公告)日： 2009-09-02
- 发明人: PENDRI YADAGIRI R , CHEN CHUNG-PIN H , PATEL SUNIL S , EVANS JEFFREY M , LIANG JING , KRONENTHAL DAVID R , POWERS GERALD L , PRASAD SIVA JOSYULA , BIEN JEFFREY T , SHI ZHONGPING , PATEL RAMESH N , CHAN YEUNG Y , RIJHWANI SUSHIL K , SINGH AMBARISH K , WANG SHAOPENG , STOJANOVIC MILAN , POLNIASZEK RICHARD , LEWIS CHARLES , THOTTATHIL JOHN , KRISHNAMURTY DHILEEPKUMAR
- 申请人： SQUIBB BRISTOL MYERS CO
- 专利权人： SQUIBB BRISTOL MYERS CO
- 当前专利权人： SQUIBB BRISTOL MYERS CO
- 优先权： US43254902 2002-12-11
- 主分类号： C07D473/18
- IPC分类号： C07D473/18 ; C07D473/12 ; C07F7/08 ; C07F7/18
摘要：
Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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