公开(公告)号：EP1644384A4

公开(公告)日：2009-09-02

申请号：EP03812974

申请日：2003-12-10

申请人： SQUIBB BRISTOL MYERS CO

发明人： PENDRI YADAGIRI R ,  CHEN CHUNG-PIN H ,  PATEL SUNIL S ,  EVANS JEFFREY M ,  LIANG JING ,  KRONENTHAL DAVID R ,  POWERS GERALD L ,  PRASAD SIVA JOSYULA ,  BIEN JEFFREY T ,  SHI ZHONGPING ,  PATEL RAMESH N ,  CHAN YEUNG Y ,  RIJHWANI SUSHIL K ,  SINGH AMBARISH K ,  WANG SHAOPENG ,  STOJANOVIC MILAN ,  POLNIASZEK RICHARD ,  LEWIS CHARLES ,  THOTTATHIL JOHN ,  KRISHNAMURTY DHILEEPKUMAR

IPC分类号： C07D473/18 ,  C07D473/12 ,  C07F7/08 ,  C07F7/18

CPC分类号： C07F7/1856 ,  C07D473/18 ,  C07F7/0812 ,  C07F7/0814 ,  C07F7/0818 ,  C07F7/0827 ,  C07F7/083

摘要： Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.