发明公开
- 专利标题： COMPOUNDS FOR MODULATING CELL PROLIFERATION
- 专利标题（中）： 调节细胞增殖的化合物
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申请号： EP04738022.5申请日： 2004-07-30
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公开(公告)号： EP1654220A1公开(公告)日： 2006-05-10
- 发明人: ROIFMAN, Chaim, M. , DEMIN, Peter , ROUNOVA, Olga , GRUNBERGER, Thomas , CIMPEAN, Octavian, Laurand
- 申请人： THE HOSPITAL FOR SICK CHILDREN
- 申请人地址： 555 University Avenue, Suite 5270 Toronto, Ontario M5G 1X8 CA
- 专利权人： THE HOSPITAL FOR SICK CHILDREN
- 当前专利权人： THE HOSPITAL FOR SICK CHILDREN
- 当前专利权人地址： 555 University Avenue, Suite 5270 Toronto, Ontario M5G 1X8 CA
- 代理机构： Benedum, Ulrich Max
- 优先权： US491109P 20030730
- 国际公布： WO2005012234 20050210
- 主分类号： C07C255/41
- IPC分类号： C07C255/41 ; C07C255/38 ; C07C255/32 ; C07D213/71 ; A61P35/00
摘要：
Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-(Cl-6a1kyl), N(C1-6a1kyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n = 1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.
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