公开(公告)号：EP1453500A1

公开(公告)日：2004-09-08

申请号：EP02767023.1

申请日：2002-10-11

申请人： THE HOSPITAL FOR SICK CHILDREN

发明人： ROIFMAN, Chaim, M. ,  GRUNBERGER, Thomas ,  SHARFE, Nigel ,  ROUNOVA, Olga B. ,  DEMIN, Peter M. ,  FREYWALD, Andrew

IPC分类号： A61K31/277 ,  A61P15/06

CPC分类号： A61K31/277

摘要： The invention relates to the use of organic compounds, styryl acrylonitrile compounds to promote myelopoiesis. These compounds thefore may be used to treat a subject suffering from neutropenia and other conditions which would benefit from increased myelopoieses. Moreover, the compounds may be used to treat hematopoietic cells ex-vivo to promote myelopoiesis and therefore may be used advantageously in bone marrow or peripheral blood stem cell transplant.

公开(公告)号：EP1467967B1

公开(公告)日：2011-04-27

申请号：EP03700255.7

申请日：2003-01-17

申请人： THE HOSPITAL FOR SICK CHILDREN

发明人： ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  GRUNBERGER, Thomas ,  ROUNOVA, Olga ,  CIMPEAN, Octavian Laurand

IPC分类号： C07C255/41 ,  A61K31/165

CPC分类号： C07C255/41 ,  C07C317/46 ,  C07D213/71

摘要： The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Fomula (I), (II), wherein R1, R2 and R3 are each independently selected from H, OH, C1-6 alkyl, C1-6 alkoxy, NH2, NH-C1-6alkyl, N(C1-6 alkyl)(C1-6 alkyl), SH, S-C1-6 alkyl, NO2, CF3, OCF3 and halo; R4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C1-6 alkyl, C1-6 alkoxy and halo; X is selected from (CH2CH2O)n and (CH2)n, and n=1-4.

公开(公告)号：EP1654220A1

公开(公告)日：2006-05-10

申请号：EP04738022.5

申请日：2004-07-30

申请人： THE HOSPITAL FOR SICK CHILDREN

发明人： ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  ROUNOVA, Olga ,  GRUNBERGER, Thomas ,  CIMPEAN, Octavian, Laurand

IPC分类号： C07C255/41 ,  C07C255/38 ,  C07C255/32 ,  C07D213/71 ,  A61P35/00

CPC分类号： A61K31/4402 ,  C07C255/41 ,  C07C323/46 ,  C07D213/71

摘要： Compounds having the Formula (I) or (III) wherein R1, R2 and R3 are each independently selected from H, OH, C1-6alkyl, C1-6alkoxy, NH2, NH-(Cl-6a1kyl), N(C1-6a1kyl)(C1-6alkyl), SH, S-C1-6alkyl, NO2, CF3, OCF3, and halo; R4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C1-6alkyl, C1-6alkoxy and halo; X is selected from (CH2CH2O)n and (CH)n, and n = 1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.

摘要翻译： 其中R 1，R 2和R 3各自独立地选自H，OH，C 1-6烷基，C 1-6烷氧基，NH 2，NH-（C 1-6烷基），N（C 1-6烷基） （C 1-6烷基），SH，S-C 1-6烷基，NO 2，CF 3，OCF 3和卤素; R4是未取代的Ar或被1-4个独立选自C1-6烷基，C1-6烷氧基和卤素的取代基取代的Ar; 描述了用于调节或抑制细胞增殖的X选自（CH 2 CH 2 O）n和（CH）n，并且n = 1-4，其盐，溶剂化物和水合物。

公开(公告)号：EP1467967A1

公开(公告)日：2004-10-20

申请号：EP03700255.7

申请日：2003-01-17

申请人： The Hospital for Sick Children

发明人： ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  GRUNBERGER, Thomas ,  ROUNOVA, Olga ,  CIMPEAN, Octavian Laurand

IPC分类号： C07C255/41 ,  C07C309/73 ,  A61K31/165

CPC分类号： C07C255/41 ,  C07C317/46 ,  C07D213/71

摘要： The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Fomula (I), (II), wherein R1, R2 and R3 are each independently selected from H, OH, C1-6 alkyl, C1-6 alkoxy, NH2, NH-C1-6alkyl, N(C1-6 alkyl)(C1-6 alkyl), SH, S-C1-6 alkyl, NO2, CF3, OCF3 and halo; R4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C1-6 alkyl, C1-6 alkoxy and halo; X is selected from (CH2CH2O)n and (CH2)n, and n=1-4.