发明公开
EP1682538A4 BIARYL LINKED HYDROXAMATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
审中-公开
BIARYLGEBUNDENDE羟肟酸：生产和制药应用
- 专利标题： BIARYL LINKED HYDROXAMATES: PREPARATION AND PHARMACEUTICAL APPLICATIONS
- 专利标题（中）： BIARYLGEBUNDENDE羟肟酸：生产和制药应用
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申请号： EP04775673申请日： 2004-10-26
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公开(公告)号： EP1682538A4公开(公告)日： 2009-05-27
- 发明人: STUNKEL WALTER , WANG HAISHAN , YIN ZHENG
- 申请人： S BIO PTE LTD
- 专利权人： S BIO PTE LTD
- 当前专利权人： S BIO PTE LTD
- 优先权： US51401203 2003-10-27; US53261503 2003-12-29
- 主分类号： C07D417/04
- IPC分类号： C07D417/04 ; A61K31/34 ; A61K31/381 ; A61K31/415 ; A61K31/421 ; A61K31/426 ; A61K31/427 ; A61P35/00 ; C07D231/14 ; C07D231/44 ; C07D261/18 ; C07D263/32 ; C07D263/34 ; C07D277/28 ; C07D277/40 ; C07D277/42 ; C07D277/46 ; C07D307/52 ; C07D307/54 ; C07D307/68 ; C07D333/38 ; C07D333/70 ; C07D405/10 ; C07D405/12 ; C07D407/14 ; C07D409/04 ; C07D409/12 ; C07D409/14 ; C07D417/12 ; C07D417/14
摘要：
The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to biaryl containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities. Formula (I), where Z is a single bond or C 1 -C 4 hydrocarbon, A is an aromatic ring, B is an aromatic ring.
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