发明公开
EP1789795A1 PATTERNED SURFACES WITH CHEMICAL CROSSLINKERS FOR USE IN DIFFRACTION-BASED SENSING
审中-公开
含化学交联剂FOR USE传感ON DIFFRAKTIONSBASIS EYED曲面
- 专利标题: PATTERNED SURFACES WITH CHEMICAL CROSSLINKERS FOR USE IN DIFFRACTION-BASED SENSING
- 专利标题(中): 含化学交联剂FOR USE传感ON DIFFRAKTIONSBASIS EYED曲面
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申请号: EP05772167.2申请日: 2005-08-04
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公开(公告)号: EP1789795A1公开(公告)日: 2007-05-30
- 发明人: GOH, M., Cynthia , GOH, Jane, B. , LOO, Richard
- 申请人: Axela Biosensors Inc.
- 申请人地址: 480 University Avenue, Suite 910 Toronto, Ontario M5G 1V2 CA
- 专利权人: Axela Biosensors Inc.
- 当前专利权人: Axela Biosensors Inc.
- 当前专利权人地址: 480 University Avenue, Suite 910 Toronto, Ontario M5G 1V2 CA
- 代理机构: Schmitz, Jean-Marie
- 优先权: US598438P 20040804
- 国际公布: WO2006012744 20060209
- 主分类号: G01N33/543
- IPC分类号: G01N33/543 ; G01N21/47 ; C12Q1/68
摘要:
Fabrication of surfaces patterned with chemical crosslinkers for solution-phase immobilization of probe molecules and their use in diffraction-based sensing. In one embodiment of the invention, a chemical crosslinker, X1 - R1 -Y1, is deposited on areas of the substrate surface that defines a pattern and allowed to react with the surface for a sufficient period of time to attain the desired density of covalently linked crosslinkers on the surface. The reaction between the crosslinker X1 - R1 - Y1 and the surface can be accelerated using known techniques such as heating, microwave irradiation, sonication, etc, to achieve the desired density in less time. In another embodiment of the invention, two or more other types of cross-linkers may also be laid down in patterns on the surface to detect for two or more other types of molecules in solution.
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