发明公开
EP1791832A1 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS
审中-公开
4-（杂芳基和取代杂芳基）咪唑-2-硫酮ASα2-肾上腺素能激动剂作用
- 专利标题： 4-(HETEROARYL-METHYL AND SUBSTITUTED HETEROARYL-METHYL)-IMIDAZOLE-2-THIONES ACTING AS ALPHA2 ADRENERGIC AGONISTS
- 专利标题（中）： 4-（杂芳基和取代杂芳基）咪唑-2-硫酮ASα2-肾上腺素能激动剂作用
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申请号： EP05796248.2申请日： 2005-09-07
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公开(公告)号： EP1791832A1公开(公告)日： 2007-06-06
- 发明人: HEIDELBAUGH, Todd, M. , CHOW, Ken , NGUYEN, Phong, X. , GIL, Daniel, W. , DONELLO, John, E. , GARST, Michael, E. , WHEELER, Larry, A.
- 申请人： ALLERGAN, INC.
- 申请人地址： 2525 Dupont Drive Irvine, CA 92612 US
- 专利权人： ALLERGAN, INC.
- 当前专利权人： ALLERGAN, INC.
- 当前专利权人地址： 2525 Dupont Drive Irvine, CA 92612 US
- 代理机构： HOFFMANN EITLE
- 优先权： US612945P 20040924
- 国际公布： WO2006036507 20060406
- 主分类号： C07D403/06
- IPC分类号： C07D403/06 ; C07D401/06 ; C07D409/06 ; C07D405/06 ; A61K31/4178 ; A61K31/437 ; A61K31/4439 ; A61P1/12 ; A61P7/12 ; A61P9/12 ; A61P29/00 ; A61P37/00
摘要：
Compounds of formula (I) where the variables have the meaning defined in the specification are agonists of alpha2 adrenergic receptors. Several compounds of the disclosure are specific or selective to alpha2B and/or alpha2C adrenergic receptors in preference over alpha2A adrenergic receptors. Additionally some of the claimed compounds have no or only minimal cardivascular and/or sedatory activity. The compounds of formula (I) are useful as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors. Compounds of formula (I) which have no significant cardiovascular and/or sedatory activity are useful for treating pain and other conditions with minimal side effects.
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