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1.发明公开HETEROCYCLYL SUBSTITUTED FUSED CARBOCYLES USEFUL IN THE TREATMENT OF CONDITIONS SUCH AS GLAUCOMA AND PAIN 审中-公开FOR患青光眼和PAIN SUITABLE杂环基 - 取代的稠CARBO CYCLEN于治疗
公开(公告)号：EP2188262A1
公开(公告)日：2010-05-26
申请号：EP08797859.9
申请日：2008-08-14
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh, C. , BHAT, Smita, S. , HEIDELBAUGH, Todd, M. , GIL, Daniel, W. , CHOW, Ken , GARST, Michael, E.
IPC分类号： C07D233/50 , C07D263/28 , C07D277/18 , A61K31/4168
CPC分类号： C07D233/44 , C07D233/50 , C07D263/28 , C07D277/18
摘要： Disclosed herein is a compound having a structure (I), compositions, methods, and medicaments related thereto are also disclosed.
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2.发明公开
公开(公告)号：EP2265269A1
公开(公告)日：2010-12-29
申请号：EP09723978.4
申请日：2009-03-24
申请人： Allergan, Inc.
发明人： TAKEUCHI, Janet, A. , LI, Ling , HEIDELBAUGH, Todd, M. , CHOW, Ken , KEDZIE, Karen, M. , GIL, Daniel, W. , FANG, Wenkui, K.
IPC分类号： A61K31/4166 , A61K31/421 , A61K31/426 , A61P25/02 , A61P25/04 , A61P43/00 , A61K31/00
CPC分类号： A61K31/4164 , A61K31/421 , A61K31/426
摘要： The invention provides methods for treating pain in mammals. In particular, the invention provides well-defined aminoimidazolines, aminothiazolines, and aminooxazo lines and pharmaceutical compositions thereof to treat pain.
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3.发明公开
公开(公告)号：EP2240468A1
公开(公告)日：2010-10-20
申请号：EP09702233.9
申请日：2009-01-14
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/4439 , C07D233/48 , A61P25/00
CPC分类号： C07D401/12 , C07D233/48 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention provides well-defined heterocyclic compounds that are useful as subtype selective alpha 2 adrenergic agonists. As such, the compounds described herein are useful in treating a wide variety of disorders associated with selective subtype modulation of alpha 2 adrenergic receptors.
摘要翻译： 本发明提供了可用作亚型选择性α2肾上腺素能激动剂的定义明确的杂环化合物。 如此，本文所述的化合物可用于治疗与α2肾上腺素能受体的选择性亚型调节有关的多种病症。
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公开(公告)号：EP2160386A1
公开(公告)日：2010-03-10
申请号：EP08755996.9
申请日：2008-05-21
申请人： ALLERGAN, INC.
IPC分类号： C07D401/06 , A61K31/4725 , A61P29/00
CPC分类号： C07D401/06
摘要： Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了式（I）的化合物还公开了与其相关的治疗方法，组合物和药物。
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5.发明公开UNSUBSTITUTED AND SUBSTITUTED 4-BENZYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONES ACTING AS SPECIFIC OR SELECTIVE ALPHA2 ADRENERGIC AGONISTS AND METHODS FOR USING THE SAME 审中-公开未取代的和取代的4-苄基-1,3-二氢咪唑-2-硫酮AS特定的或 选择性α-2-肾上腺素受体激动剂的工作，申请流程。
公开(公告)号：EP1797044A2
公开(公告)日：2007-06-20
申请号：EP05796348.0
申请日：2005-09-07
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , NGUYEN, Phong, X. , GIL, Daniel, W. , DONELLO, John, E. , GARST, Michael, E. , WHEELER, Larry, A. , CAPPIELLO, John, R.
IPC分类号： C07D233/84 , A61K31/4174 , A61P37/00 , A61P29/00 , A61P9/12 , A61P7/12 , A61P1/12
CPC分类号： A61K31/4166 , C07D233/84
摘要： Compounds of Formula 1 (I) where the variables have the meaning defined in the specification are used to activate alpha2 adrenergic receptors. The compounds of Formula 1 are incorporated in pharmaceutical compositions and are used as medicaments in mammals, including humans, for treatment of diseases and or alleviations of conditions which are responsive to treatment by agonists of alpha2 adrenergic receptors.
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6.发明授权1-(2,3-DIMETHYL-PHENYL)-ETHYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONE AS NON-SEDATING ALPHA 2A AGONIST 有权1-（2,3-二甲基 - 苯基） - 乙基-1,3-二氢 - 咪唑-2-硫酮作为非镇静ALPHA 2A激动剂
公开(公告)号：EP1663206B1
公开(公告)日：2007-04-04
申请号：EP04781753.1
申请日：2004-08-20
申请人： ALLERGAN, INC.
IPC分类号： A61K31/4174 , A61P1/00 , A61P9/00 , C07D233/84
CPC分类号： A61K31/4164 , C07D233/84
摘要： The present invention provides an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. The present invention further provides a pharmaceutical composition that contains a pharmaceutical carrier and a therapeutically effective amount of an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof.
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7.发明公开NONSEDATING A-2 AGONIST 1-(2,3-DIMETHYL-PHENYL)-ETHYL-1,3-DIHYDRO-IMIDAZOLE-2-THIONE 有权1-（2,3-二甲基 - 苯基） - 乙基-1,3-二氢 - 咪唑-2-硫酮作为非镇静ALPHA 2A激动剂
公开(公告)号：EP1663206A1
公开(公告)日：2006-06-07
申请号：EP04781753.1
申请日：2004-08-20
申请人： ALLERGAN, INC.
IPC分类号： A61K31/4164 , A61P1/00 , A61P9/00 , C07D233/84
CPC分类号： A61K31/4164 , C07D233/84
摘要： The present invention provides an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof. The present invention further provides a pharmaceutical composition that contains a pharmaceutical carrier and a therapeutically effective amount of an α-2A/α-1A selective agonist that includes a compound represented by Structure 1 or a pharmaceutically acceptable salt, ester, amide, sterioisomer or racemic mixture thereof.
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8.发明授权METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS USING IMIDAZOLINE DERIVATIVES 有权使用咪唑啉衍生物治疗α肾上腺素能调节的方法
公开(公告)号：EP2303264B1
公开(公告)日：2018-04-04
申请号：EP09763343.2
申请日：2009-06-05
申请人： ALLERGAN, INC.
发明人： FANG, Wenkui, K. , NGUYEN, Phong, X. , CHOW, Ken , HEIDELBAUGH, Todd, M. , GOMEZ, Dario, G. , GARST, Michael, E. , SINHA, Santosh, C. , Daniel W. Gil , John E. Donello
IPC分类号： A61K31/4168 , A61P9/12
CPC分类号： A61K31/4168
摘要： Described herein are compounds for use in a method of treating a condition or disease in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an ±-adrenergic modulator. The compounds are also useful for alleviating types of pain, both acute and chronic.
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9.发明授权SUBSTITUTED 3-AMINO-1-OXO OR THIOXO-1,2,5,6,7,8-HEXAHYDRO-2,7-NAPHTHYRIDINE-4-CARBONITRILES AS SELECTIVE ALPHA 2B ANTAGONISTS 有权取代的3-氨基-1-氧代或硫代-1,2,5,6,7,8-六氢-2,7-萘啶-4-甲腈，为选择性拮抗剂ALPHA 2B
公开(公告)号：EP2334676B1
公开(公告)日：2016-07-06
申请号：EP09792255.3
申请日：2009-09-04
申请人： ALLERGAN, INC.
发明人： CAPPIELLO, John, R. , CHOW, Ken , HEIDELBAUGH, Todd, M. , TAKEUCHI, Janet, A. , GARST, Michael, E. , GIL, Daniel, W. , KEDZIE, Karen, M. , DONELLO, John, E.
IPC分类号： C07D471/04 , A61K31/4745 , A61P29/00
CPC分类号： C07D471/04
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10.发明授权
公开(公告)号：EP2249834B1
公开(公告)日：2015-05-13
申请号：EP09702616.5
申请日：2009-01-15
申请人： ALLERGAN, INC.
发明人： HEIDELBAUGH, Todd, M. , CHOW, Ken , SINHA, Santosh, C. , NGUYEN, Phong, X. , FANG, Wenkui, K. , LI, Ling , TAKEUCHI, Janet, A. , BHAT, Smita, S.
IPC分类号： A61K31/4439 , A61K31/497 , A61P29/00
CPC分类号： A61K31/4439 , A61K31/497
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