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公开(公告)号：EP2970239B1
公开(公告)日：2018-10-10
申请号：EP14723161.7
申请日：2014-03-12
申请人： ALLERGAN, INC.
发明人： TAKEUCHI, Janet A. , LI, Ling , CHOW, Ken , IM, Wha Bin
IPC分类号： C07D413/10 , A61K31/416 , A61P3/04 , C07D213/75 , C07D405/12 , C07D409/12
CPC分类号： C07D409/12 , C07D213/75 , C07D213/76 , C07D405/12 , C07D413/10
摘要： The present invention relates to novel pyridine or pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. The invention relates specifically to the use of these compounds and their pharmaceutical compositions to treat disorders associated with chemokine receptor modulation.
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公开(公告)号：EP2964267A1
公开(公告)日：2016-01-13
申请号：EP14712948.0
申请日：2014-03-06
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh C. , CHOW, Ken , WANG, Liming , BHAT, Smita S. , SWIFT, Brandon D. , ATTAR, Mayssa , GARST, Michael E.
IPC分类号： A61K47/48 , A61P27/02 , A61P29/00 , A61P31/04 , C07D215/56
CPC分类号： A61K47/48115 , A61K9/0048 , A61K47/552 , A61K47/554 , C07J41/005 , C07J43/003
摘要： The present invention describes novel single drug entities, formed by the linkage of an antibiotic with a steroidal drug via a linker. Upon topical application to the eye, the conjugate would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
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3.发明授权NOVEL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS 有权NEW氮杂环丁烷衍生物ALS鞘氨醇-1-磷酸（S1P）受体调节剂
公开(公告)号：EP2646023B1
公开(公告)日：2015-01-07
申请号：EP11788690.3
申请日：2011-11-09
申请人： ALLERGAN, INC.
发明人： FANG, Wenkui K. , CHOW, Ken , WANG, Liming , CORPUZ, Evelyn G. , IM, Wha Bin
IPC分类号： A61K31/41 , C07D413/10 , C07D413/14 , A61P9/10
CPC分类号： C07D413/14 , A61K31/397 , A61K31/41 , A61K31/4245 , C07D413/10
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公开(公告)号：EP2491017B1
公开(公告)日：2014-08-27
申请号：EP10769130.5
申请日：2010-10-20
申请人： ALLERGAN, INC.
IPC分类号： C07D207/22 , A61K31/40 , A61P29/00 , A61P25/18 , A61P17/06
CPC分类号： C07D207/22
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5.发明公开NOVEL OXIME DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS 有权新型肟衍生物ALS鞘氨醇-1-磷酸（S1P）受体调节剂
公开(公告)号：EP2646114A1
公开(公告)日：2013-10-09
申请号：EP11788319.9
申请日：2011-11-18
申请人： Allergan, Inc.
发明人： FANG, Wenkui, K. , WANG, Liming , CORPUZ, Evelyn, G. , CHOW, Ken , IM, Wha Bin
IPC分类号： A61P9/10 , A61K31/197 , A61K31/662 , C07F9/38
CPC分类号： C07F9/3834 , C07C229/34 , C07F9/3808
摘要： The present invention relates to novel oxime derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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6.发明公开NOVEL AZETIDINE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS 有权NEW氮杂环丁烷衍生物ALS鞘氨醇-1-磷酸（S1P）受体调节剂
公开(公告)号：EP2646023A1
公开(公告)日：2013-10-09
申请号：EP11788690.3
申请日：2011-11-09
申请人： Allergan, Inc.
发明人： FANG, Wenkui K. , CHOW, Ken , WANG, Liming , CORPUZ, Evelyn G. , IM, Wha Bin
IPC分类号： A61K31/41 , C07D413/10 , C07D413/14 , A61P9/10
CPC分类号： C07D413/14 , A61K31/397 , A61K31/41 , A61K31/4245 , C07D413/10
摘要： The present invention relates to novel azetidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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7.发明公开NOVEL PHENYL OXADIAZOLE DERIVATIVES AS SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTOR MODULATORS 有权NEW PHENYLOXADIAZOLDERIVATE ALS鞘氨醇-1-磷酸（S1P）受体调节剂
公开(公告)号：EP2646022A1
公开(公告)日：2013-10-09
申请号：EP11788293.6
申请日：2011-11-14
申请人： Allergan, Inc.
发明人： FANG, Wenkui K. , WANG, Liming , CORPUZ, Evelyn G. , CHOW, Ken , IM, Wha Bin
IPC分类号： A61K31/41 , C07D271/06 , C07F9/38 , A61P9/10
CPC分类号： C07D271/06 , A61K31/41 , A61K31/4245 , A61K31/675 , C07F9/65318
摘要： The present invention relates to novel phenyl oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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公开(公告)号：EP2643297A1
公开(公告)日：2013-10-02
申请号：EP11787988.2
申请日：2011-11-10
申请人： Allergan, Inc.
发明人： SINHA, Santosh C. , BHAT, Smita S. , CHOW, Ken , GARST, Michael E. , IM, Wha Bin
IPC分类号： C07D209/42 , C07D403/12 , C07D413/04 , C07D413/14 , A61K31/4245 , A61K31/405 , A61K31/443 , A61P27/02 , A61P9/10 , A61P17/02 , A61P19/00 , A61P19/10 , A61P25/00 , A61P25/28 , A61P29/00
CPC分类号： C07D413/14 , C07D209/42 , C07D403/12 , C07D413/04
摘要： The present invention relates to novel indole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
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公开(公告)号：EP2018364B1
公开(公告)日：2013-08-21
申请号：EP07783755.7
申请日：2007-05-15
申请人： ALLERGAN, INC.
IPC分类号： C07C275/24 , C07D213/40 , C07D307/52 , C07D333/20 , A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61P25/04
CPC分类号： C07C275/24 , C07C2601/08 , C07C2601/14 , C07D213/40 , C07D307/52 , C07D333/20
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10.发明公开ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL]METHANOL FOR TREATING RETINAL DISEASES 有权[3-（1-（1H-咪唑-4-基）乙基）-2-甲基苯基]甲醇用于治疗视网膜疾病的前药酯
公开(公告)号：EP2616066A1
公开(公告)日：2013-07-24
申请号：EP11760958.6
申请日：2011-09-16
申请人： Allergan, Inc.
发明人： DIBAS, Mohammed I. , GIL, Daniel W. , CHOW, Ken , WANG, Liming , GARST, Michael E. , DONELLO, John E.
IPC分类号： A61K31/4174 , A61P27/06
CPC分类号： A61K31/4174 , A61K9/0014 , A61K31/4164 , C07D233/64 , Y10S514/912
摘要： The present invention relates to method of treating retinal diseases in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising a ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.
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