发明公开
EP1824860A2 THIENOPYRIDYL COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF
审中-公开
香草素受体亚型1（VR1）炎症及其用途THIENOPYRIDYLVERBINDUNGEN
- 专利标题： THIENOPYRIDYL COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF
- 专利标题（中）： 香草素受体亚型1（VR1）炎症及其用途THIENOPYRIDYLVERBINDUNGEN
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申请号： EP05853428.0申请日： 2005-12-07
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公开(公告)号： EP1824860A2公开(公告)日： 2007-08-29
- 发明人: TURNER, Sean, C. , JINKERSON, Tammie, K. , GOMTSYAN, Arthur, R. , LEE, Chih-hung
- 申请人： ABBOTT LABORATORIES
- 申请人地址： Dept. 377 Bldg. AP6A-1, 100 Abbott Park Road Abbott Park, Illinois 60064-6008 US
- 专利权人： ABBOTT LABORATORIES
- 当前专利权人： ABBOTT LABORATORIES
- 当前专利权人地址： Dept. 377 Bldg. AP6A-1, 100 Abbott Park Road Abbott Park, Illinois 60064-6008 US
- 代理机构： Modiano, Micaela Nadia
- 优先权： US633957P 20041207
- 国际公布： WO2006063178 20060615
- 主分类号： C07D495/04
- IPC分类号： C07D495/04 ; A61K31/4365 ; A61P13/10 ; A61P29/00
摘要：
The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.
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