公开(公告)号：EP2146985A1

公开(公告)日：2010-01-27

申请号：EP07865508.1

申请日：2007-12-12

申请人： ABBOTT LABORATORIES

发明人： LEE, Chih-hung ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael, R. ,  SIPPY, Kevin, B. ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D413/14 ,  A61K31/4245 ,  A61P25/28

CPC分类号： C07D413/14

摘要： The invention relates to heterocyclic derivatives, compositions comprising such compounds, and methods of preventing or treating conditions and disorders using such compounds and compositions. The heterocyclic derivatives, more particularly can be substituted oxadiazole compounds and derivatives thereof.

公开(公告)号：EP2231672A1

公开(公告)日：2010-09-29

申请号：EP08853111.6

申请日：2008-11-20

申请人： Abbott Laboratories

发明人： JI, Jianguo ,  LI, Tao ,  SIPPY, Kevin B ,  LEE, Chih-hung ,  GOPALAKRISHNAN, Murali

IPC分类号： C07D487/04 ,  A61K31/407 ,  A61P25/00

CPC分类号： C07D487/04

摘要： The invention relates biaryl substituted diazabicycloalkanes of foraula (I), and more particularly bicycloheteroaryl substituted fused diazabicycloalkane derivatives, compositions comprising such compounds, and such compounds for use for treating or preventing conditions and disorders related to both

摘要翻译： 本发明涉及方（（I）的联芳基取代的二氮杂双环烷烃，更具体地涉及双环杂芳基取代的稠合二氮杂双环烷烃衍生物，包含此类化合物的组合物，以及用于治疗或预防与

公开(公告)号：EP2099795A2

公开(公告)日：2009-09-16

申请号：EP07863920.0

申请日：2007-11-06

申请人： ABBOTT LABORATORIES

发明人： SCHRIMPF, Michael R ,  NERSESIAN, Diana L ,  SIPPY, Kevin B ,  JI, Jianguo ,  LI, Tao ,  SCANIO, Marc ,  SHI, Lei ,  LEE, Chih-hung ,  BUNNELLE, Willaim H ,  ZHANG, Geoff G.Z. ,  BRACKEMEYER, Paul J ,  CHEN, Shuang ,  HENRY, Rodger F

IPC分类号： C07D451/14 ,  A61K31/395

CPC分类号： C07D471/18 ,  A61K31/095 ,  A61K31/439 ,  A61K31/444 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07C309/29 ,  C07D451/14 ,  C07D471/08 ,  C07F5/022

摘要： The invention relates to compounds that are azaadamantane derivatives of formula (I), particularly ether- or amine -substituted azaadamantane derivatives and salts and prodrugs thereof, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

公开(公告)号：EP1844038A2

公开(公告)日：2007-10-17

申请号：EP05825417.8

申请日：2005-11-22

申请人： ABBOTT LABORATORIES

发明人： GOMTSYAN, Arthur, R. ,  BAYBURT, Erol, K. ,  SCHMIDT, Robert, G., Jr. ,  LEE, Chih-hung ,  BROWN, S. Brian ,  JINKERSON, K. Tammie ,  KOENIG, R. John ,  DAANEN, F. Jerome ,  LATSHAW, Steve

IPC分类号： C07D405/00

CPC分类号： C07D405/12 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.

公开(公告)号：EP2101763B1

公开(公告)日：2012-07-18

申请号：EP07869109.4

申请日：2007-12-12

申请人： ABBOTT LABORATORIES

发明人： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC分类号： A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC分类号： A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

公开(公告)号：EP2054390B1

公开(公告)日：2012-04-11

申请号：EP07814410.2

申请日：2007-08-24

申请人： ABBOTT LABORATORIES

发明人： LEE, Chih-hung ,  BROWN, Brian, S. ,  PERNER, Richard, J. ,  DARBYSHIRE, John

IPC分类号： C07D231/56 ,  A61K31/416 ,  A61P25/00

CPC分类号： A61K31/416 ,  C07D231/56

摘要： Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2114943A1

公开(公告)日：2009-11-11

申请号：EP07854782.5

申请日：2007-11-27

申请人： ABBOTT LABORATORIES

发明人： JI, Jianguo ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B ,  LI, Tao ,  LEE, Chih-hung

IPC分类号： C07D471/18 ,  A61K31/395 ,  A61P25/02 ,  A61P25/28

CPC分类号： C07D471/18

摘要： The invention relates to compounds that are spirocyclic azaadamantane derivatives (I), particularly spirocyclic, azaadamantanyl ether or amine derviatives, compositions comprising such compounds, methods of using such compounds and compositions, processes for preparing such compounds, and intermediates obtained during such processes.

公开(公告)号：EP2054390A1

公开(公告)日：2009-05-06

申请号：EP07814410.2

申请日：2007-08-24

申请人： ABBOTT LABORATORIES

发明人： LEE, Chih-hung ,  BROWN, Brian, S. ,  PERNER, Richard, J. ,  DARBYSHIRE, John

IPC分类号： C07D231/56 ,  A61K31/416 ,  A61P25/00

CPC分类号： A61K31/416 ,  C07D231/56

摘要： Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

公开(公告)号：EP2101763A2

公开(公告)日：2009-09-23

申请号：EP07869109.4

申请日：2007-12-12

申请人： ABBOTT LABORATORIES

发明人： GOPALAKRISHNAN, Murali ,  HONORE, Marie P. ,  LEE, Chih-hung ,  MALYSZ, John ,  JI, Jianguo ,  LI, Tao ,  SCHRIMPF, Michael R. ,  SIPPY, Kevin B. ,  ANDERSON, David J.

IPC分类号： A61K31/4245 ,  A61P25/28 ,  A61K45/06

CPC分类号： A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

摘要： The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

公开(公告)号：EP1824860A2

公开(公告)日：2007-08-29

申请号：EP05853428.0

申请日：2005-12-07

申请人： ABBOTT LABORATORIES

发明人： TURNER, Sean, C. ,  JINKERSON, Tammie, K. ,  GOMTSYAN, Arthur, R. ,  LEE, Chih-hung

IPC分类号： C07D495/04 ,  A61K31/4365 ,  A61P13/10 ,  A61P29/00

CPC分类号： C07D495/04 ,  C07D498/04

摘要： The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.