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1.发明公开CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF 审中-公开SUBTYP 1（VR1）受体的抑制香草素CHROMANYLHARNSTOFFVERBINDUNGEN及其用途
公开(公告)号：EP1844038A2
公开(公告)日：2007-10-17
申请号：EP05825417.8
申请日：2005-11-22
申请人： ABBOTT LABORATORIES
发明人： GOMTSYAN, Arthur, R. , BAYBURT, Erol, K. , SCHMIDT, Robert, G., Jr. , LEE, Chih-hung , BROWN, S. Brian , JINKERSON, K. Tammie , KOENIG, R. John , DAANEN, F. Jerome , LATSHAW, Steve
IPC分类号： C07D405/00
CPC分类号： C07D405/12 , C07D401/12 , C07D403/12 , C07D413/12
摘要： Compounds that are antagonists of the VR1 receptor, having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein A1, A2, A3, A4, R7, R8, R9, X, Y, Z, L, n, and m, are as defined herein, and are useful in disorders prevented or ameliorated by inhibiting the VR1 receptor.
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2.发明公开FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363A1
公开(公告)日：2004-11-24
申请号：EP03716014.0
申请日：2003-02-11
申请人： Abbott Laboratories
发明人： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC分类号： A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC分类号： C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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3.发明授权FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR 有权CONDENSED AZABICYCLISCHEVERBINDUNGEN作为香草素受体1的抑制剂（VR1）
公开(公告)号：EP1478363B1
公开(公告)日：2009-01-14
申请号：EP03716014.0
申请日：2003-02-11
申请人： ABBOTT LABORATORIES
发明人： LEE, Chih-Hung , BAYBURT, Erol, K. , DIDOMENICO, Stanley Jr. , DRIZIN, Irene , GOMTSYAN, Arthur, R. , KOENIG, John R. , PERNER, Richard, J. , SCHMIDT, Robert G. , TURNER, Sean C. , WHITE, Tammie, K. , ZHENG, Guo, Zhu
IPC分类号： A61K31/502 , C07D217/02 , C07D237/28 , C07D217/22 , C07D209/08 , C07D231/56 , A61K31/472 , A61K31/416 , A61K31/404
CPC分类号： C07D249/08 , A61K31/404 , A61K31/416 , A61K31/47 , A61K31/472 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D217/02 , C07D217/22 , C07D217/24 , C07D217/26 , C07D231/12 , C07D231/56 , C07D233/56 , C07D237/28 , C07D401/12 , C07D405/12
摘要： Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
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4.发明公开THIENOPYRIDYL COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) AND USES THEREOF 审中-公开香草素受体亚型1（VR1）炎症及其用途THIENOPYRIDYLVERBINDUNGEN
公开(公告)号：EP1824860A2
公开(公告)日：2007-08-29
申请号：EP05853428.0
申请日：2005-12-07
申请人： ABBOTT LABORATORIES
IPC分类号： C07D495/04 , A61K31/4365 , A61P13/10 , A61P29/00
CPC分类号： C07D495/04 , C07D498/04
摘要： The present invention discloses fused thienopyridyl compounds of general formula (I), wherein X1-X6, R5-R7, Z1 and L are as defined in the description. The resent invention also discloses a method for inhibiting the VR1 receptor in mammals using these compounds, a method for controlling pain, urinary incontinence, bladder overactivity, and inflammatory thermal hyperalgesia in mammals, and pharmaceutical compositions including those compounds.
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5.发明授权2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN 有权2- AMINOOXAZOLDERIVATE AS疼痛SUITABLE的TRPV1拮抗剂的治疗
公开(公告)号：EP2220059B1
公开(公告)日：2011-08-03
申请号：EP08841479.2
申请日：2008-10-25
申请人： Abbott Laboratories
发明人： PERNER, Richard J. , KOENIG, John R. , DIDOMENICO, Stanley, Jr. , BAYBURT, Erol, K. , DAANEN, Jerome, F. , GOMTSYAN, Arthur, R. , KORT, Michael E. , KYM, Philip R. , VASUDEVAN, Anil , SCHMIDT, Robert, G. , VOIGHT, Eric
IPC分类号： C07D263/48 , C07D413/04 , C07D413/12 , A61K31/421 , A61P29/00
CPC分类号： C07D413/12 , C07D263/48 , C07D413/04
摘要： Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
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6.发明公开2-AMINOOXAZOLE DERIVATIVES AS TRPVL ANTAGONISTS USEFUL FOR TREATING PAIN 有权2-AMINOOXAZOLE DERIVATIVES TRPVL ANTAGONISTS用于治疗疼痛
公开(公告)号：EP2220059A1
公开(公告)日：2010-08-25
申请号：EP08841479.2
申请日：2008-10-25
申请人： Abbott Laboratories
发明人： PERNER, Richard J. , KOENIG, John R. , DIDOMENICO, Stanley, Jr. , BAYBURT, Erol, K. , DAANEN, Jerome, F. , GOMTSYAN, Arthur, R. , KORT, Michael E. , KYM, Philip R. , VASUDEVAN, Anil , SCHMIDT, Robert, G. , VOIGHT, Eric
IPC分类号： C07D263/48 , C07D413/04 , C07D413/12 , A61K31/421 , A61P29/00
CPC分类号： C07D413/12 , C07D263/48 , C07D413/04
摘要： Compounds of formula (I) wherein R1, R2, R4, and W are defined in the description are TRPV1 antagonists with CNS penetration. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also disclosed.
摘要翻译： 其中R 1，R 2，R 4和W在说明书中定义的式（I）化合物是具有CNS穿透的TRPV1拮抗剂。 还公开了包含此类化合物的组合物以及使用此类化合物和组合物治疗疾病和病症的方法。
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公开(公告)号：EP1957464A1
公开(公告)日：2008-08-20
申请号：EP06817391.3
申请日：2006-10-27
申请人： ABBOTT LABORATORIES
发明人： GOMTSYAN, Arthur, R. , BAYBURT, Erol, K. , KOENIG, John, R. , MARSH, Kennan, C. , SCHMIDT, Robert, G., Jr. , LEE, Chih-Hung , WANG, Weili , DAANEN, Jerome, F. , BROWN, Brian, S.
IPC分类号： C07D231/56 , C07D407/12 , A61K31/416 , A61P13/00
CPC分类号： C07D405/12 , C07D231/56 , C07D403/12 , C07F9/65038
摘要： Compounds of formula (I), wherein A, R1, R2, and R3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivity, urinary incontinence, and other disorders caused by or exacerbated by TRPV1.
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8.发明授权TRISUBSTITUTED-N- (1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS 有权（1S）-1,2,3,4-四氢-1-萘酰基]苯甲酰胺类化合物，其抑制含P2X3和P2X2 / 3的受体
公开(公告)号：EP1392643B1
公开(公告)日：2005-09-14
申请号：EP02739257.0
申请日：2002-05-14
申请人： ABBOTT LABORATORIES
发明人： LEE, Chih-Hung , PERNER, Richard, J. , LARSON, Daniel, P. , KOENIG, John, R. , GOMTSYAN, Arthur, R. , ZHENG, Guo Zhu , DIDOMENICO, Stanley , STEWART, Andrew, O. , BAYBURT, Erol, K.
IPC分类号： C07C233/74 , A61K31/166 , A61K31/18 , A61P21/00
CPC分类号： C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
摘要： Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
摘要翻译： 式（I）化合物是新型P2X3和P2X2 / P2X3拮抗剂，其可用于治疗疼痛，尿失禁和膀胱过度活动。
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9.发明公开TRISUBSTITUTED-N- (1S)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENYL] BENZAMIDES WHICH INHIBIT P2X3 AND P2X2/3 CONTAINING RECEPTORS 有权三取代-N - （（1S）-1,2,3,4-四氢-1-萘基）苯甲酰胺WHAT P2X3和P2X2 / 3 CONTAINING受体INHIBIT
公开(公告)号：EP1392643A2
公开(公告)日：2004-03-03
申请号：EP02739257.0
申请日：2002-05-14
申请人： Abbott Laboratories
发明人： LEE, Chih-Hung , PERNER, Richard, J. , LARSON, Daniel, P. , KOENIG, John, R. , GOMTSYAN, Arthur, R. , ZHENG, Guo Zhu , DIDOMENICO, Stanley , STEWART, Andrew, O. , BAYBURT, Erol, K.
IPC分类号： C07C233/74 , A61K31/166 , A61K31/18 , A61P21/00
CPC分类号： C07D213/40 , C07D213/68 , C07D213/71 , C07D239/34 , C07D309/12 , C07D317/72 , C07D333/20 , C07D333/34 , C07D333/72
摘要： Compounds of formula (I), are novel P2X3 and P2X2/P2X3 antagonists which are useful in treating pain, urinary incontinence and bladder overactivity.
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