发明公开
EP1827504A2 RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO ESCAPE THE ENDOSOME
有权
重组BCG具有改进的能力，从逃出内体菌株
- 专利标题： RECOMBINANT BCG STRAINS WITH ENHANCED ABILITY TO ESCAPE THE ENDOSOME
- 专利标题（中）： 重组BCG具有改进的能力，从逃出内体菌株
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申请号： EP05858631.4申请日： 2005-11-23
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公开(公告)号： EP1827504A2公开(公告)日： 2007-09-05
- 发明人: SUN, Ronggai , HONE, David, Michael , SADOFF, Jerald, C.
- 申请人： Aeras Global TB Vaccine Foundation
- 申请人地址： 7500 Old Georgetown Road, Suite 800 Bethesda, MD 20814 US
- 专利权人： Aeras Global TB Vaccine Foundation
- 当前专利权人： Aeras Global TB Vaccine Foundation
- 当前专利权人地址： 7500 Old Georgetown Road, Suite 800 Bethesda, MD 20814 US
- 代理机构： Kröncke, Rolf
- 优先权： US631973P 20041201
- 国际公布： WO2007058663 20070524
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A01N63/00 ; C12N1/12 ; C12N1/20
摘要：
Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains.
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