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1.发明公开RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS 有权重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
公开(公告)号：EP2235163A1
公开(公告)日：2010-10-06
申请号：EP08853526.5
申请日：2008-11-26
发明人： SHAFFERMAN, Avigdor , ZVI, Anat , ARIEL, Naomi , FULKERSON, John , SUN, Ronggai , CHANG, Rosemary , SADOFF, Jerald, C.
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
摘要： A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
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公开(公告)号：EP1830877A2
公开(公告)日：2007-09-12
申请号：EP05858632.2
申请日：2005-11-23
CPC分类号： A61K39/04 , A61K39/0011 , A61K2039/522 , A61K2039/523 , C12N1/36 , C12N9/0089 , C12Y115/01001
摘要： Strains of Mycobaterium that have decreased immunosuppressive properties are provided. The Mycobaterium strains are genetically engineered to express but not secrete super-oxide dismutase (Sod). The presence of cytosol bound Sod allows replication and growth of the Mycobacterium, but does not result in attenuation of the host immune response. The Mycobacterium strains provide improved properties for use as vaccines.
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3.发明授权RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS 有权重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
公开(公告)号：EP2235163B1
公开(公告)日：2014-01-08
申请号：EP08853526.5
申请日：2008-11-26
发明人： SHAFFERMAN, Avigdor , ZVI, Anat , ARIEL, Naomi , FULKERSON, John , SUN, Ronggai , CHANG, Rosemary , SADOFF, Jerald, C.
IPC分类号： C12N7/00 , A61K39/00 , A61K39/04 , C07K14/195 , C12N15/52
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
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4.发明授权
公开(公告)号：EP1827504B1
公开(公告)日：2011-05-11
申请号：EP05858631.4
申请日：2005-11-23
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains.
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5.发明公开
公开(公告)号：EP1827504A2
公开(公告)日：2007-09-05
申请号：EP05858631.4
申请日：2005-11-23
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains.
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