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1.发明公开RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN-BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF 审中-公开重组结核分枝编码肝素结合血细胞凝集素（HBHA）的融合蛋白及其用途
公开(公告)号：EP2838990A1
公开(公告)日：2015-02-25
申请号：EP12874533.8
申请日：2012-04-16
申请人： Aeras Global TB Vaccine Foundation , INSERM - Institut National de la Santé et de la Recherche Médicale
CPC分类号： C07K14/35 , A61K39/04 , A61K49/0006 , A61K2039/523 , A61K2039/53 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/90
摘要： Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.
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2.发明公开ENHANCEMENT OF TRANSGENE EXPRESSION FROM VIRAL-BASED VACCINE VECORS BY EXPRESSION OF SUPPRESSORS OF THE TYPE I INTERFERON RESPONSE 审中-公开改进疫苗载体的转基因表达对BASIS按类别划分的抑制器病毒表达我干扰素反应
公开(公告)号：EP2190979A4
公开(公告)日：2011-08-24
申请号：EP08798942
申请日：2008-08-29
发明人： SADOFF JERALD C , FULKERSON JOHN , FAKRUDDIN-JAMILUDDIN MOHAMAD , STONE MICHELE R , ANANTHA RAVI
CPC分类号： A61K39/04 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/55516 , C12N15/86 , C12N2710/10343 , C12N2710/14043 , C12N2710/14143 , C12N2760/16134 , C12N2840/203
摘要： Viral-based vectors are genetically engineered to express inhibitors of the anti-viral immune system (e.g. inhibitors of the type I interferon response) in order to enhance transgene expression. The transgenes may encode antigens or other therapeutic agents.
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3.发明公开RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS 有权重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
公开(公告)号：EP2235163A1
公开(公告)日：2010-10-06
申请号：EP08853526.5
申请日：2008-11-26
发明人： SHAFFERMAN, Avigdor , ZVI, Anat , ARIEL, Naomi , FULKERSON, John , SUN, Ronggai , CHANG, Rosemary , SADOFF, Jerald, C.
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
摘要： A vaccine against Mycobacteria tuberculosis (Mtb) is provided. The vaccine comprises a recombinant Bacille Calmette-Guerin (BCG) subunit-based vaccine in which one or more Mtb antigens and one or more Mtb resuscitation or reactivation antigens are overexpressed, and in which at least a portion of the DosR regulon is up-regulated. The vaccine is protective against active Mtb infection both pre- and post-exposure to Mtb, and thus prevents disease symptoms due to the recurrence of a latent Mtb infection.
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4.发明公开MALARIA VACCINE COMPOSITIONS AND CONSTITUENTS WHICH ELICIT CELL MEDIATED IMMUNITY 审中-公开疟疾疫苗组合物和成分，细胞介导的免疫RELEASE
公开(公告)号：EP2249857A4
公开(公告)日：2012-02-29
申请号：EP09701498
申请日：2009-01-12
发明人： SHAFFERMAN AVIGDOR , ZVI ANAT , FULKERSON JOHN , SADOFF JERALD C
IPC分类号： A61K38/08 , C07K7/00 , C07K7/08 , C07K14/445
CPC分类号： C07K14/445 , C07K7/08
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5.发明公开BACTERIAL PACKAGING STRAINS USEFUL FOR GENERATION AND PRODUCTION OF RECOMBINANT DOUBLE-STRANDED RNA NUCLEOCAPSIDS AND USES THEREOF 审中-公开创建和生产重组双链RNA核衣壳有用的细菌包装费用及其用途
公开(公告)号：EP2170385A4
公开(公告)日：2011-06-29
申请号：EP08827487
申请日：2008-05-30
发明人： HONE DAVID , FULKERSON JOHN , SADOFF JERALD C , ONYABE DAVID , STONE MICHELE
IPC分类号： A61K39/295 , C12N15/74
CPC分类号： C12N15/88 , A61K39/04 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/57 , C12N15/86 , C12N2770/24211 , C12N2770/36143 , C12N2840/203
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6.发明公开ENHANCEMENT OF TRANSGENE EXPRESSION FROM VIRAL-BASED VACCINE VECORS BY EXPRESSION OF SUPPRESSORS OF THE TYPE I INTERFERON RESPONSE 审中-公开改进疫苗载体的转基因表达对BASIS按类别划分的抑制器病毒表达我干扰素反应
公开(公告)号：EP2190979A1
公开(公告)日：2010-06-02
申请号：EP08798942.2
申请日：2008-08-29
发明人： SADOFF, Jerald, C. , FULKERSON, John , FAKRUDDIN-JAMILUDDIN, Mohamad , STONE, Michele, R. , ANANTHA, Ravi
CPC分类号： A61K39/04 , A61K39/12 , A61K39/145 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/55516 , C12N15/86 , C12N2710/10343 , C12N2710/14043 , C12N2710/14143 , C12N2760/16134 , C12N2840/203 , Y02A50/386 , Y02A50/394 , Y02A50/412 , Y02A50/466
摘要： Viral-based vectors are genetically engineered to express inhibitors of the anti-viral immune system (e.g. inhibitors of the type I interferon response) in order to enhance transgene expression. The transgenes may encode antigens or other therapeutic agents.
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公开(公告)号：EP1937800A2
公开(公告)日：2008-07-02
申请号：EP06815322.0
申请日：2006-09-26
发明人： KOLE, Manoj
摘要： Biocompatible medium and non-ionic polymer surfactants such as tyloxapol may be used in a composition for preserving cells, such as bacterial cells. Cells may be preserved, for example, by suspending them in a biocompatible medium containing tyloxaopol and preserving the suspension. Examples of a preservation procedure are drying by foam formulation, glacification, dessication, spray drying, fluidized bed drying, drying in a vacuum, drying in a dry atmosphere, and drying at a high temperature in the range of 15 - 35°C.
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8.发明公开RECOMBINANT BCG TUBERCULOSIS VACCINE FOR ELICITING IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS 有权重组卡介苗对结核病诱导免疫反应对结核分枝杆菌的
公开(公告)号：EP2235163A4
公开(公告)日：2012-08-01
申请号：EP08853526
申请日：2008-11-26
发明人： SHAFFERMAN AVIGDOR , ZVI ANAT , ARIEL NAOMI , FULKERSON JOHN , SUN RONGGAI , CHANG ROSEMARY , SADOFF JERALD C
IPC分类号： C12N7/00 , A61K39/00 , A61K39/04 , C07K14/195 , C12N15/52
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/53 , C07K14/35
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9.发明公开STABLE, SPRAY DRIED, IMMUNOGENIC, VIRAL COMPOSITIONS 有权STABLE，SPRÜHGETROCKNETE，免疫原性VIRUSZUSAMMENSETZUNGEN
公开(公告)号：EP2432502A2
公开(公告)日：2012-03-28
申请号：EP10778366.4
申请日：2010-05-20
发明人： JIN, Tom, Han , TSAO, Eric, I-Fu
IPC分类号： A61K39/12 , A61K39/235 , C12N15/861 , C12N15/33
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2710/10334 , C12N2710/10343 , C12N2710/10351 , C12N2710/10361 , Y02A50/386 , Y02A50/412 , Y02A50/466
摘要： Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, MVA viruses, and baculoviruses which encode one or more antigens of interest, such as TB, malarial, and HIV antigens, are spray dried with a mannitol-cyclodextrin-trehalose-dextran (MCTD) to form a powder where the viability of the viruses are maintained at a suitable level for mass vaccinations after spray drying, and where the viability of the viruses are maintained at suitable level over a period of storage time, even in the presence of humidity.
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10.发明授权
公开(公告)号：EP1827504B1
公开(公告)日：2011-05-11
申请号：EP05858631.4
申请日：2005-11-23
CPC分类号： A61K39/04 , A61K2039/522 , A61K2039/523 , C07K14/33 , Y02A50/412
摘要： Mycobacterium strains that have an enhanced ability to elicit a Histocompatibility-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell. The invention also provides vaccine preparations containing the Mycobacterium strains.
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