发明公开
EP1828143A1 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS
有权
2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
- 专利标题： 2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS
- 专利标题（中）： 2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
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申请号： EP05823957.5申请日： 2005-12-15
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公开(公告)号： EP1828143A1公开(公告)日： 2007-09-05
- 发明人: CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
- 申请人： Merck Frosst Canada Ltd.
- 申请人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 专利权人： Merck Frosst Canada Ltd.
- 当前专利权人： Merck Frosst Canada Ltd.
- 当前专利权人地址： 16711 Trans-Canada Highway Kirkland, Québec H9H 3L1 CA
- 代理机构： Buchan, Gavin MacNicol
- 优先权： US637180P 20041217; US739338P 20051123
- 国际公布： WO2006063466 20060622
- 主分类号： C07D235/02
- IPC分类号： C07D235/02 ; C07D403/04 ; C07D401/04 ; A61K31/4164 ; A61K31/4439
摘要：
The invention encompasses novel compounds of Formula I INSERT FORMULA I FROM CLAIM 1 or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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