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1.发明公开2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1828143A1
公开(公告)日：2007-09-05
申请号：EP05823957.5
申请日：2005-12-15
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
IPC分类号： C07D235/02 , C07D403/04 , C07D401/04 , A61K31/4164 , A61K31/4439
CPC分类号： C07D401/14 , C07D235/02 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I INSERT FORMULA I FROM CLAIM 1 or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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2.发明公开
公开(公告)号：EP1989187A1
公开(公告)日：2008-11-12
申请号：EP07719387.8
申请日：2007-02-22
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , HAMEL, Pierre
IPC分类号： C07D235/02 , A61K31/4184
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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3.发明授权ALKYNE-ARYL-NAPHTHYRIDIN-4(1H)-0NE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITOR 有权作为IV型磷酸二酯酶抑制剂的烷基 - 芳基 - 萘啶-4（1H） - 烯衍生物
公开(公告)号：EP1436290B1
公开(公告)日：2013-09-18
申请号：EP02754079.8
申请日：2002-08-27
IPC分类号： C07D471/04 , C07D519/00 , A61K31/435
CPC分类号： A61K45/06 , A61K31/435 , A61K31/4375 , C07D471/04 , A61K2300/00
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4.发明授权2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1828143B1
公开(公告)日：2013-03-20
申请号：EP05823957.5
申请日：2005-12-15
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
IPC分类号： C07D235/02 , C07D403/04 , C07D401/04 , A61K31/4164 , A61K31/4439
CPC分类号： C07D401/14 , C07D235/02 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D413/06
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公开(公告)号：EP2024371A1
公开(公告)日：2009-02-18
申请号：EP07719789.5
申请日：2007-05-15
发明人： COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GIROUX, Andre , MARTINS, Evelyn , HAMEL, Pierre
IPC分类号： C07D495/04 , A61K31/4188 , C07D487/04 , C07D491/04 , C07D495/14
CPC分类号： C07D491/04 , C07D471/04 , C07D495/04 , C07D495/14
摘要： The invention encompasses novel compounds of Formula or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmacuetical compositions are also encompassed.
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6.发明公开[1,2,3]TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS 有权[1,2,3] - 三唑基 - 取代CHINO LINE AND AS香豆素白三烯生物合成抑制剂
公开(公告)号：EP2118093A1
公开(公告)日：2009-11-18
申请号：EP08714553.8
申请日：2008-02-05
发明人： DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GAREAU, Yves , GRIMM, Erich, L. , JUTEAU, Helene , LALIBERTE, Sebastien , MACKAY, Bruce
IPC分类号： C07D405/06 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61P11/06 , A61P29/00 , A61P37/08 , A61P9/10 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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7.发明公开2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO(9,10-D)IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H-菲并（9,10-D）咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1954683A1
公开(公告)日：2008-08-13
申请号：EP06817652.8
申请日：2006-11-21
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
IPC分类号： C07D235/02 , A61K31/4184 , C07D401/04 , C07D401/06 , C07D405/06 , C07D413/06
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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8.发明公开THIADIAZOLE SUBSTITUTED COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITOR 有权噻二唑取代的香豆素衍生物及其作为白三烯生物合成抑制剂的用途
公开(公告)号：EP1869031A1
公开(公告)日：2007-12-26
申请号：EP06741360.9
申请日：2006-03-21
发明人： BLOUIN, Marc , GRIMM, Erich, L. , GAREAU, Yves , GAGNON, Marc , JUTEAU, Helene , LALIBERTE, Sebastien , MACKAY, Bruce , FRIESEN, Richard
IPC分类号： C07D413/12 , C07D417/12 , A61K31/4245 , A61P19/02 , A61K31/433
CPC分类号： C07D417/14 , C07D413/12 , C07D417/12
摘要： The instant invention provides compounds of Formula (Ia) which are leukotriene biosynthesis inhibitors, wherein X is O or S, Y is O, S, -NR6-CHR7- or -NR8-C(O)- and A is selected from 5-membered aromatic heterocyclic ring, 6-membered aromatic heterocyclic ring, naphthelenic or heterobicyclic aromatic ring system, phenyl and benzyl. A is optionally mono- or disubstituted. Compounds of Formula (Ia) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
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9.发明公开7-[(1,3-THIAZOL-2-YL)THIO]-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS 审中-公开7 - [（1,3-噻唑-2-基）硫代] -COUMARINDERIVATIVE及其作为白三烯生物合成的抑制剂
公开(公告)号：EP1636222A1
公开(公告)日：2006-03-22
申请号：EP04737802.1
申请日：2004-06-08
发明人： GAREAU, Yves , JUTEAU, Helene , MACKAY, Bruce, D. , FRIESEN, Richard , GRIMM, Erich, L. , BLOUIN, Marc , LALIBERTE, Sebastien
IPC分类号： C07D417/12 , A61K31/427 , C07D417/14
CPC分类号： C07D417/12 , C07D277/36 , C07D417/14
摘要： The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory, cytoprotective and anti-artherosclerotic agents.
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