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1.发明公开2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1828143A1
公开(公告)日：2007-09-05
申请号：EP05823957.5
申请日：2005-12-15
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
IPC分类号： C07D235/02 , C07D403/04 , C07D401/04 , A61K31/4164 , A61K31/4439
CPC分类号： C07D401/14 , C07D235/02 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D413/06
摘要： The invention encompasses novel compounds of Formula I INSERT FORMULA I FROM CLAIM 1 or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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2.发明公开
公开(公告)号：EP1989187A1
公开(公告)日：2008-11-12
申请号：EP07719387.8
申请日：2007-02-22
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , HAMEL, Pierre
IPC分类号： C07D235/02 , A61K31/4184
CPC分类号： C07D235/02 , C07D401/04 , C07D403/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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3.发明授权2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO[9,10-D]IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H- PHENANTRO [9,10，D〕咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1828143B1
公开(公告)日：2013-03-20
申请号：EP05823957.5
申请日：2005-12-15
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
IPC分类号： C07D235/02 , C07D403/04 , C07D401/04 , A61K31/4164 , A61K31/4439
CPC分类号： C07D401/14 , C07D235/02 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/06 , C07D413/06
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4.发明公开2-(PHENYL OR HETEROCYCLIC)-1H-PHENANTRHO(9,10-D)IMIDAZOLES AS MPGES-1 INHIBITORS 有权2-（苯基或杂环基）-1H-菲并（9,10-D）咪唑ALS的mPGES-1抑制剂
公开(公告)号：EP1954683A1
公开(公告)日：2008-08-13
申请号：EP06817652.8
申请日：2006-11-21
发明人： CHAU, Anh , COTE, Bernard , DUCHARME, Yves , FRENETTE, Richard , FRIESEN, Richard , GAGNON, Marc , GIROUX, Andre , MARTINS, Evelyn , YU, Hongping , WU, Tom
IPC分类号： C07D235/02 , A61K31/4184 , C07D401/04 , C07D401/06 , C07D405/06 , C07D413/06
CPC分类号： C07D235/02 , C07D235/18 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D413/04 , C07D413/06
摘要： The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
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