发明授权
- 专利标题： INHIBITORS OF E1 ACTIVATING ENZYMES
- 专利标题（中）： HEMMER VON E1-AKTIVIERENDEN ENZYMEN
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申请号： EP06734691.6申请日： 2006-02-02
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公开(公告)号： EP1848718B1公开(公告)日： 2012-08-01
- 发明人: CRITCHLEY, Stephen , GANT, Thomas, G. , LANGSTON, Steven, P. , OLHAVA, Edward, J. , PELUSO, Stephane
- 申请人： MILLENNIUM PHARMACEUTICALS, INC.
- 申请人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人： MILLENNIUM PHARMACEUTICALS, INC.
- 当前专利权人地址： 40 Landsdowne Street Cambridge, MA 02139 US
- 代理机构： Harris, Jennifer Lucy
- 优先权： US650433P 20050204
- 国际公布： WO2006084281 20060810
- 主分类号： C07D473/34
- IPC分类号： C07D473/34 ; A61K31/52 ; A61P35/00
摘要：
This invention relates to compounds of formula (I-A) wherein Ring A and the variables X, Y, R3a, R3b, R3c, R3d, R4, R5, R5′, and m are defined herein. The compounds of formula (I-A) inhibit E1 activating enzymes, pharmaceutical compositions comprising the compounds, and methods of using the compounds. The compounds of the invention are useful for treating disorders, particularly cell proliferation disorders, including cancers, inflammatory and neurodegenerative disorders; and inflammation associated with infection and cachexia.
公开/授权文献
- EP1848718A1 INHIBITORS OF E1 ACTIVATING ENZYMES 公开/授权日：2007-10-31
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