发明公开
EP1848983A1 FLUORESCENCE CORRELATION MICROSCOPY WITH REAL-TIME ALIGNMENT READOUT
有权
具有实时对准读出式荧光相关显微镜
- 专利标题： FLUORESCENCE CORRELATION MICROSCOPY WITH REAL-TIME ALIGNMENT READOUT
- 专利标题（中）： 具有实时对准读出式荧光相关显微镜
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申请号： EP05736243.6申请日： 2005-02-15
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公开(公告)号： EP1848983A1公开(公告)日： 2007-10-31
- 发明人: MAITI, Sudipta, Tata Institute of Fundamental , KAUSHALYA, Sanjeev K., Tata Institute of Fundamen. , GARAI, Kanchan, Tata Institute of Fundamental , BALAJI, Jayaprakash, Tata Institute of Fundamental
- 申请人： Tata Institute of Fundamental Research
- 申请人地址： Homi Bhabha Road, Colaba Mumbai 400 005, Maharashtra IN
- 专利权人： Tata Institute of Fundamental Research
- 当前专利权人： Tata Institute of Fundamental Research
- 当前专利权人地址： Homi Bhabha Road, Colaba Mumbai 400 005, Maharashtra IN
- 代理机构： Maiwald, Walter
- 国际公布： WO2006087727 20060824
- 主分类号： G01N21/64
- IPC分类号： G01N21/64 ; G02B21/00 ; G01J3/457
摘要：
This invention relates to a confocal fluorescence correlation microscope with real-time alignment read out. With this instrument it is possible to do confocal imaging together with the particle size determination at a chosen location in the specimen. In particular, this invention relates to a detector module with a fixed aperture and detection electronics that can be conveniently connected to an existing confocal or multiphoton microscope, near the base of the objective lens of the microscope. This detector splits a part of the signal and uses it to generate a spot on the confocal image. This shows the spot where an FCS measurement can be carried out, and the same signal can then be used to perform a fluorescence correlation measurement after parking the excitation beam of the confocal to that spot. No alignment step is necessary for obtaining the measurement.
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