发明公开
EP1855696A2 9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY
有权
9A-羧乙基-Y-氨基丙烯酰胺-9-氨基]亚氨基-γ-氨基丙酸 - 马来酸盐麻醉剂抗菌药物
- 专利标题： 9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY
- 专利标题（中）： 9A-羧乙基-Y-氨基丙烯酰胺-9-氨基]亚氨基-γ-氨基丙酸 - 马来酸盐麻醉剂抗菌药物
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申请号： EP06727593.3申请日： 2006-01-13
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公开(公告)号： EP1855696A2公开(公告)日： 2007-11-21
- 发明人: BUKVIC KRAJACIC, Mirjana , KUJUNDZIC, Nedjeljko , IVEZIC, Zrinka , ALIHODZIC, Sulejman , HUTINEC, Antun , FAJDETIC, Andrea
- 申请人： GlaxoSmithKline istrazivacki centar Zagreb d.o.o.
- 申请人地址： Prilaz Baruna Filipovica 29 10000 Zagreb HR
- 专利权人： GlaxoSmithKline istrazivacki centar Zagreb d.o.o.
- 当前专利权人： GlaxoSmithKline istrazivacki centar Zagreb d.o.o.
- 当前专利权人地址： Prilaz Baruna Filipovica 29 10000 Zagreb HR
- 代理机构： Crawley, Karen Anne
- 优先权： US644360P 20050114
- 国际公布： WO2006085228 20060817
- 主分类号： A61K31/7052
- IPC分类号： A61K31/7052 ; A61P33/06 ; C07H17/08
摘要：
Novel 9a-N'-substituted-carbamoyl- and thiocarbamoyl-aminoalkyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds having antimalarial activity are claimed. More particularly, the invention relates to 9a-N'-substituted-carbamoyl- and thiocarbamoyl-beta-aminoethyl- or -gamma-aminopropyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
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