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公开(公告)号：EP2012776A2
公开(公告)日：2009-01-14
申请号：EP07734526.2
申请日：2007-05-01
发明人： ALIHODZIC, Sulejman , FAJDETIC, Andrea , HUTINEC, Antun , IVEZIC, Zrinka , KUJUNDZIC, Nedjeljko , RUPCIC, Renata
IPC分类号： A61K31/395 , A61K31/7052 , A61P33/06
CPC分类号： A61K31/395 , A61K31/7052 , Y02A50/411
摘要： The present invention relates to novel 9a-substituted azalides having antimalarial activity. More particularly, the invention relates to 9a-substituted 9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A, 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-5-O-dedesosaminyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds having antimalarial activity, to the method of preparation, to the method of use, and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
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2.发明公开9A-CARBAMOYL AND THIOCARBAMOYL AZALIDES WITH ANTIMALARIAL ACTIVITY 有权9A氨基甲酰和THIOCARBAMOYLAZALIDE具有抗疟疾行动
公开(公告)号：EP1841437A2
公开(公告)日：2007-10-10
申请号：EP06744666.6
申请日：2006-01-12
IPC分类号： A61K31/7048 , A61P33/06
CPC分类号： A61K31/7048 , A61K31/70 , Y02A50/411
摘要： 9a-carbamoyl and thiocarbamoyl azalides A and their pharmaceutically acceptable derivatives are useful for treatment and prevention of malaria.
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3.发明授权9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY 有权具有抗疟活性的9A-氨基甲酰基-γ-氨基丙基 - 和9A-氨基甲酰基-γ-氨基丙酰基 - 唾液酸
公开(公告)号：EP1835921B1
公开(公告)日：2010-08-18
申请号：EP06727577.6
申请日：2006-01-12
IPC分类号： A61K31/7052 , A61P33/06
CPC分类号： A61K31/7052 , Y02A50/411
摘要： 9a-Carbamoyl-gamma-aminopropyl- and 9a-thiocarbamoyl-gamma-aminopropyl-azalides and their pharmaceutically acceptable derivatives are useful for treatment and prevention of malaria.
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4.发明公开9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY 有权9A-羧乙基-Y-氨基丙烯酰胺-9-氨基]亚氨基-γ-氨基丙酸 - 马来酸盐麻醉剂抗菌药物
公开(公告)号：EP1855696A2
公开(公告)日：2007-11-21
申请号：EP06727593.3
申请日：2006-01-13
发明人： BUKVIC KRAJACIC, Mirjana , KUJUNDZIC, Nedjeljko , IVEZIC, Zrinka , ALIHODZIC, Sulejman , HUTINEC, Antun , FAJDETIC, Andrea
IPC分类号： A61K31/7052 , A61P33/06 , C07H17/08
CPC分类号： A61K31/7052 , C07H17/08 , Y02A50/411
摘要： Novel 9a-N'-substituted-carbamoyl- and thiocarbamoyl-aminoalkyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds having antimalarial activity are claimed. More particularly, the invention relates to 9a-N'-substituted-carbamoyl- and thiocarbamoyl-beta-aminoethyl- or -gamma-aminopropyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
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5.发明授权9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY 有权9A氨基甲酰-Y-氨丙基和9A-硫代-Y-丙基 - 氮杂内酯抗疟疾活动
公开(公告)号：EP1855696B1
公开(公告)日：2010-04-28
申请号：EP06727593.3
申请日：2006-01-13
发明人： BUKVIC KRAJACIC, Mirjana , KUJUNDZIC, Nedjeljko , IVEZIC, Zrinka , ALIHODZIC, Sulejman , HUTINEC, Antun , FAJDETIC, Andrea
IPC分类号： A61K31/7052 , A61P33/06 , C07H17/08
CPC分类号： A61K31/7052 , C07H17/08 , Y02A50/411
摘要： Novel 9a-N'-substituted-carbamoyl- and thiocarbamoyl-aminoalkyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds having antimalarial activity are claimed. More particularly, the invention relates to 9a-N'-substituted-carbamoyl- and thiocarbamoyl-beta-aminoethyl- or -gamma-aminopropyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A and 3-O-decladinosyl-9a-aza-9-deoxo-9-dihydro-9a-homoerythromycin A compounds and to pharmaceutically acceptable derivatives thereof having antimalarial activity.
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6.发明授权9A-CARBAMOYL AND THIOCARBAMOYL AZALIDES WITH ANTIMALARIAL ACTIVITY 有权9A氨基甲酰和THIOCARBAMOYLAZALIDE具有抗疟疾行动
公开(公告)号：EP1841437B1
公开(公告)日：2009-04-29
申请号：EP06744666.6
申请日：2006-01-12
IPC分类号： A61K31/7048 , A61P33/06
CPC分类号： A61K31/7048 , A61K31/70 , Y02A50/411
摘要： 9a-carbamoyl and thiocarbamoyl azalides A and their pharmaceutically acceptable derivatives are useful for treatment and prevention of malaria.
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7.发明公开9A-CARBAMOYL-Y-AMINOPROPYL- AND 9A-THIOCARBAMOYL-Y-AMINOPROPYL-AZALIDES WITH ANTIMALARIAL ACTIVITY 有权具有抗疟活性的9A-氨基甲酰基-γ-氨基丙基 - 和9A-氨基甲酰基-γ-氨基丙酰基 - 唾液酸
公开(公告)号：EP1835921A2
公开(公告)日：2007-09-26
申请号：EP06727577.6
申请日：2006-01-12
IPC分类号： A61K31/7052 , A61P33/06
CPC分类号： A61K31/7052 , Y02A50/411
摘要： 9a-Carbamoyl-gamma-aminopropyl- and 9a-thiocarbamoyl-gamma-aminopropyl-azalides and their pharmaceutically acceptable derivatives are useful for treatment and prevention of malaria.
摘要翻译： 9a-氨基甲酰基-γ-氨基丙基 - 和9a-硫代氨基甲酰基-β-氨基丙基 - 氮化物及其药学上可接受的衍生物可用于治疗和预防疟疾。
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