发明授权
EP1882697B1 Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins
有权
结合抗体，抗体片段和scFv改性翻译后到神经营养因子
- 专利标题： Antibodies, antibody fragments and scFv binding to post-translationally modified neurotrophins
- 专利标题（中）： 结合抗体，抗体片段和scFv改性翻译后到神经营养因子
-
申请号： EP06291195.3申请日： 2006-07-24
-
公开(公告)号： EP1882697B1公开(公告)日： 2010-04-21
- 发明人: Barbeito, Luis , Pehar, Mariana , Cassina, Patricia , Alzari, Pedro M.
- 申请人： INSTITUT PASTEUR , Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) , Facultad de Medicina, Universidad de la Republica
- 申请人地址： 25-28, rue du Docteur Roux 75724 Paris Cedex 15 FR
- 专利权人： INSTITUT PASTEUR,Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.),Facultad de Medicina, Universidad de la Republica
- 当前专利权人： INSTITUT PASTEUR,Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.),Facultad de Medicina, Universidad de la Republica
- 当前专利权人地址： 25-28, rue du Docteur Roux 75724 Paris Cedex 15 FR
- 代理机构： Paris, Fabienne
- 主分类号： C07K16/22
- IPC分类号： C07K16/22 ; A61K39/395 ; A61P25/00 ; G01N33/53 ; C07K14/48 ; C07K14/475 ; C07K1/107 ; A61K38/18
摘要：
The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.
公开/授权文献
- EP1882697A1 Post-translationally modified neurotrophins 公开/授权日：2008-01-30
信息查询
