公开(公告)号：EP1882697B1

公开(公告)日：2010-04-21

申请号：EP06291195.3

申请日：2006-07-24

申请人： INSTITUT PASTEUR ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) ,  Facultad de Medicina, Universidad de la Republica

发明人： Barbeito, Luis ,  Pehar, Mariana ,  Cassina, Patricia ,  Alzari, Pedro M.

IPC分类号： C07K16/22 ,  A61K39/395 ,  A61P25/00 ,  G01N33/53 ,  C07K14/48 ,  C07K14/475 ,  C07K1/107 ,  A61K38/18

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/48

摘要： The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.

公开(公告)号：EP1882697A1

公开(公告)日：2008-01-30

申请号：EP06291195.3

申请日：2006-07-24

申请人： INSTITUT PASTEUR ,  Instituto de Investigaciones Biologicas Clemente Estable (I.I.B.C.E.) ,  Facultad de Medicina, Universidad de la Republica

发明人： Barbeito, Luis ,  Pehar, Mariana ,  Cassina, Patricia ,  Alzari, Pedro M.

IPC分类号： C07K14/48 ,  C07K14/475 ,  C07K1/107 ,  G01N33/53 ,  C07K16/22 ,  A61P25/00 ,  A61K38/18 ,  A61K39/395

CPC分类号： C07K16/22 ,  A61K38/00 ,  A61K39/3955 ,  C07K14/475 ,  C07K14/48

摘要： The present invention describes that neurotrophins undergo post-translational modifications, and that these post-translational modifications mediate the pro-apoptotic and/or pro-neurite activity of neurotrophins. These post-translational modifications notably include nitration and the formation of conformationally-different dimers, as well as of abnormal oligomers, such as tetramers and octamers. The invention further relates to compounds that compete with such modified neurotrophins, as well as to compounds that binds to said modified neurotrophins. The invention thus provides useful agents for the treatment of the conditions or diseases involving chronic pain and/or neuron loss.

摘要翻译： 本发明描述了神经营养因子经历翻译后修饰，并且这些翻译后修饰介导神经营养蛋白的促凋亡和/或前神经突活性。 这些翻译后修饰特别包括硝化和构象不同二聚体的形成，以及异构低聚物如四聚体和八聚体。 本发明还涉及与这种修饰的神经营养因子竞争的化合物，以及与所述修饰的神经营养蛋白结合的化合物。 因此，本发明提供了用于治疗涉及慢性疼痛和/或神经元损失的病症或疾病的有用试剂。