发明授权
- 专利标题: SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
- 专利标题(中): 螺羟吲哚及其作为治疗剂
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申请号: EP06750402.7申请日: 2006-04-11
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公开(公告)号: EP1888595B1公开(公告)日: 2012-02-01
- 发明人: CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
- 申请人: Xenon Pharmaceuticals Inc.
- 申请人地址: 3650 Gilmore Way Burnaby, BC V5G 4W8 CA
- 专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人: Xenon Pharmaceuticals Inc.
- 当前专利权人地址: 3650 Gilmore Way Burnaby, BC V5G 4W8 CA
- 代理机构: Grünecker, Kinkeldey, Stockmair & Schwanhäusser
- 优先权: US670896P 20050411
- 国际公布: WO2006110917 20061019
- 主分类号: C07D498/10
- IPC分类号: C07D498/10 ; A61K31/404 ; A61P29/00
摘要:
This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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