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1.发明公开PYRIDOPYRIMIDINONE COMPOUNDS USEFUL IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS 审中-公开有关钠通道介导的疾病治疗或遭受SUITABLE PYRIDOPYRIMIDINONVERBINDUNGEN
公开(公告)号：EP2079737A1
公开(公告)日：2009-07-22
申请号：EP08729067.2
申请日：2008-02-05
发明人： LIU, Shifeng , FU, Jianmin , KAMBOJ, Rajender , JIA, Qi , WOOD, Mark , CHOWDHURY, Sultan , SUN, Jianyu
IPC分类号： C07D471/04 , A61K31/505 , A61P25/00
CPC分类号： C07D471/04
摘要： This invention is directed to pyridopyrimidinone compounds of formula (I): wherein n, R1, R2 and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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2.发明公开SPIRO (FURO Ý3, 2-C¨PYRIDINE-3-3 ' -INDOL) -2' (1'H)-ONE DERIVATIVES AND RELATED COMPOUNDS FOR THE TREATMENT OF SODIUM-CHANNEL MEDIATED DISEASES, SUCH AS PAIN 审中-公开螺（呋喃并[3,2-c]吡啶3,3ý - 吲哚）-2y（1ýH）-ONDERIVATE及相关化合物用于通过酸钠处理通道介导的疾病，如疼痛
公开(公告)号：EP2076514A1
公开(公告)日：2009-07-08
申请号：EP07844225.8
申请日：2007-10-12
发明人： CADIEUX, Jean-Jacques , CHOWDHURY, Sultan , FU, Jianmin , KAMBOJ, Rajender , HSIEH, Tom , JIA, Qi , LIU, Shifeng , SUN, Jianyu
IPC分类号： C07D471/20 , A61K31/4747 , A61P25/04
CPC分类号： C07D471/22 , C07D471/20
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein j, k, m, Q, X,, R1, R2a, R2b, R2c, R2d and R3 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, N-oxide, solvate or prodrug thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：EP2350091B1
公开(公告)日：2015-06-03
申请号：EP09741118.5
申请日：2009-10-13
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Lauren , FU, Jianmin , LANGILLE, Jonathan , LIU, Shifeng , SUN, Jianyu , SUN, Shaoyi , SVIRIDOV, Serguei , WOOD, Mark , ZENOVA, Alla
IPC分类号： C07D491/20 , C07D491/107 , A61K31/407 , A61P25/00 , A61P29/00
CPC分类号： C07D491/107 , C07D491/20
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公开(公告)号：EP1888595A2
公开(公告)日：2008-02-20
申请号：EP06750402.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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公开(公告)号：EP2073806B1
公开(公告)日：2012-02-15
申请号：EP07868434.7
申请日：2007-10-12
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： A61K31/437 , A61K31/407 , A61P3/06 , A61P13/08 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
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公开(公告)号：EP1888595B1
公开(公告)日：2012-02-01
申请号：EP06750402.7
申请日：2006-04-11
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , BAGHERZADEH, Mehran Seid , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： C07D498/10 , A61K31/404 , A61P29/00
CPC分类号： C07D491/10
摘要： This invention is directed to spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain. Pharmaceutical compositions comprising the compounds and methods of preparing and using the compounds are also disclosed.
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公开(公告)号：EP2350090A2
公开(公告)日：2011-08-03
申请号：EP09740589.8
申请日：2009-10-13
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Lauren , FU, Jianmin , LANGILLE, Jonathan , LIU, Shifeng , SUN, Jianyu , SUN, Shaoyi , SVIRIDOV, Serguei , WOOD, Mark , ZENOVA, Alla , JIA, Qi , CADIEUX, Jean-Jacques , GAUTHIER, Simon, J. , DOUGLAS, Amy Frances , HSIEH, Tom , CHAKKA, Nagasree , CIKOJEVIC, Zoran
IPC分类号： C07D491/20 , C07D495/20 , C07D498/20 , C07D491/10 , C07D513/20 , A61K31/407 , A61P25/00
CPC分类号： C07D513/22 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/20 , C07D498/20 , C07D513/20 , C07D519/00
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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公开(公告)号：EP2073806A2
公开(公告)日：2009-07-01
申请号：EP07868434.7
申请日：2007-10-12
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Robert , FU, Jianmin , KAMBOJ, Rajender , HOU, Duanjie , LIU, Shifeng , SEID BAGHERZADEH, Mehran , SVIRIDOV, Serguei , SUN, Shaoyi , SUN, Jianyu , CHAKKA, Nagasree , HSIEH, Tom , RAINA, Vandna
IPC分类号： A61K31/437 , A61K31/407 , A61P3/06 , A61P13/08 , A61P17/04 , A61P35/00
CPC分类号： A61K31/407 , A61K31/437
摘要： This invention is directed to methods of using spiro-oxindole compounds of formula (I): wherein k, j, Q, R1, R2a, R2b, R2c, R2d, R3a, R3b, R3c, and R3d are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment and/or prevention of hypercholesterolemia, benign prostatic hyperplasia, pruritis and cancer.
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9.发明公开TRICYCLIC COMPOUNDS USEFUL IN TREATING IRON DISORDERS 审中-公开TRIZYKLISCHE VERBINDUNGEN ZUR BEHANDLUNG VONEISENSTOFFWECHSELSTÖRUNGEN
公开(公告)号：EP2061755A1
公开(公告)日：2009-05-27
申请号：EP08754872.3
申请日：2008-03-07
发明人： CHAFEEV, Mikhail , CHAKKA, Nagasree , CADIEUX, Jean-jacques , FU, Jianmin , KAMBOJ, Rajender , KODUMURU, Vishnumurthy , LANGILLE, Johnathan , LIU, Shifeng , SUN, Jianyu , SVIRIDOV, Serguei , ZHANG, Zaihui
IPC分类号： C07C321/20 , C07D219/02 , C07D307/91 , C07D311/82 , C07D333/50 , C07D337/10 , A61K31/155 , A61P7/00
CPC分类号： C07D337/10 , C07C335/32 , C07C2603/08 , C07C2603/18 , C07C2603/24 , C07D219/02 , C07D307/91 , C07D311/82 , C07D327/08 , C07D333/50
摘要： This invention is directed to, for example, compounds of formula (I): wherein n, m, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, as a stereoisomer, enantiomer, tautomer thereof or mixtures thereof; or a pharmaceutically acceptable salt, solvate or prodrug thereof, for the treatment of iron disorders. This invention is also directed to pharmaceutical compositions comprising the compounds and methods of using the compounds to treat iron disorders.
摘要翻译： 本发明涉及例如式（I）的化合物：其中n，m，R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8如本文所定义，为其立体异构体，对映体，互变异构体或 其混合物; 或其药学上可接受的盐，溶剂合物或前药，用于治疗铁疾病。 本发明还涉及包含该化合物的药物组合物和使用该化合物治疗铁疾病的方法。
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公开(公告)号：EP2350091A1
公开(公告)日：2011-08-03
申请号：EP09741118.5
申请日：2009-10-13
发明人： CHAFEEV, Mikhail , CHOWDHURY, Sultan , FRASER, Lauren , FU, Jianmin , LANGILLE, Jonathan , LIU, Shifeng , SUN, Jianyu , SUN, Shaoyi , SVIRIDOV, Serguei , WOOD, Mark , ZENOVA, Alla
IPC分类号： C07D491/20 , C07D491/107 , A61K31/407 , A61P25/00 , A61P29/00
CPC分类号： C07D491/107 , C07D491/20
摘要： This invention is directed to spiro-oxindole compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.
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