发明公开
- 专利标题: TRIARYLCARBOXYLIC ACID DERIVATIVE
- 专利标题(中): 三芳基羧酸衍生物
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申请号: EP06811388.5申请日: 2006-10-06
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公开(公告)号: EP1932832A1公开(公告)日: 2008-06-18
- 发明人: SATO, Junji , HATTORI, Kazuyuki , KUBOTA, Hirokazu , MUNAKATA, Ryosuke , ASANO, Toru , MAEDA, Junko , KAWAKAMI, Masakatsu , KAMIKAWA, Akio
- 申请人: Astellas Pharma Inc.
- 申请人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: 3-11, Nihonbashi-Honcho 2-chome, Chuo-ku Tokyo 103-8411 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2005295740 20051007
- 国际公布: WO2007043457 20070419
- 主分类号: C07D213/79
- IPC分类号: C07D213/79 ; A61K31/381 ; A61K31/4025 ; A61K31/404 ; A61K31/415 ; A61K31/4155 ; A61K31/42 ; A61K31/425 ; A61K31/426 ; A61K31/427 ; A61K31/4418 ; A61K31/443 ; A61K31/4436 ; A61K31/4439 ; A61K31/444 ; A61K31/4535
摘要:
It is intended to provide an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on which has a non-nucleic acid structure and exerts an excellent xanthine oxidase inhibiting action and a hypouricemic effect. It has been confirmed that a novel triarylcarboxylic acid derivative, which is characterized by having a carboxyl-substituted heteroaryl group and an aromatic ring group such as a phenyl group attached in para-position on a benzene ring and further carrying a cyano group on the same benzene ring, has a potent xanthine oxidase inhibiting action and a hypouricemic effect. Thus, it is found out that this compound is appropriately usable as an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on.
公开/授权文献
- EP1932832B1 TRIARYLCARBOXYLIC ACID DERIVATIVE 公开/授权日:2010-12-01
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